Identification, synthesis and structural determination of some impurities of candesartan cilexetil
All principal candesartan cilexetil impurities and/or degradation products were synthesized and identified. The differentiation of N-l and N-2 ethylated candesartan cilexetil derivatives was performed using ID and 2D NMR experiments. The influence of the magnetic field on the resolution and sensitivity of NMR experiments is shown. Selective hydrolysis of these compounds then provided corresponding producrs of hydrolysis of the ethoxy group. Institute of Organic Chemistry and Biochemistry.
Havllcek, Jaroslav,Mandelova, Zuzana,Weisemann, Ruediger,Strelec, Ivo,Placek, Lukas,Radl, Stanislav
experimental part
p. 347 - 362
(2009/06/28)
STABLE MICRONIZED CANDESARTAN CILEXETIL AND METHODS FOR PREPARING THEREOF
The invention encompasses sable candesartan cilexetil of fine particle size, wherein desethyl-candesartan (desethyl-CNS) within the stable candesartan cilexetil does not increase to more than about 0.1%w/w by HPLC relative to the initial amount of candesartan cilexetil, when the stable candesartan cilexetil is maintained at a temperature of about 550°C for at least 2 weeks, methods of making the same and pharmaceutical compositions thereof.
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Page/Page column 12; 13
(2008/06/13)
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