- Synthesis and biological evaluation of new coumarin derivatives as cytotoxic agents
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New coumarin derivatives 9a–f, 10a–e, and 11a–f were synthesized and evaluated for their cytotoxic activity against a human breast cancer cell line (MCF-7). All compounds exhibited good activity in the nanomolar range, using doxorubicin and erlotinib as positive controls. The most active compound 9d with IC50 of 21 nM was tested against the HCT-116, HepG-2, A549, and SGC-7901 cell lines, with IC50 values of 0.021, 0.170, 0.028, and 0.11 μM, respectively. Compound 9d was further investigated for its ability to suppress the expression of epidermal growth factor receptor (EGFR). Compound 9d decreased the concentration of EGFR by 87%, using erlotinib as a positive control. A docking study revealed similar or higher scores than for erlotinib and similar binding poses providing interactions with the hinge region of the tyrosine kinase (TK). Besides the effect on expression, this in silico investigation predicts the possibility of direct binding between the new coumarin derivatives and the EGFR TK. Moreover, computational calculation for ADME properties for the most active compounds 9d, 9e, 10c, and 11c revealed the expected high gastrointestinal tract absorption, moderate water solubility with no central nervous system toxicity, and druglikeness.
- Ragab, Fatma A.,Eissa, Amal A. M.,Fahim, Samar H.,Salem, Mohammad A.,Gamal, Mona A.,Nissan, Yassin M.
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- Novel coumarin-pyrazoline hybrids: synthesis, cytotoxicity evaluation and molecular dynamics study
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A novel series of coumarin-pyrazoline hybrids3a-f,4a-cand5a-chave been synthesized and tested for their antiproliferative activity against the breast cancer cell line MCF-7. The most active compounds3d,3e,3f,5aand5cwere also evaluated for their ability to
- Eissa, Amal A. M.,Fahim, Samar H.,Gamal, Mona A.,Nissan, Yassin M.,Ragab, Fatma A.,Salem, Mohammad Alaraby
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p. 19043 - 19055
(2021/10/26)
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- Spectroscopic and biophysical studies on chalcones and schiff bases derived from chromen-2-one and quinoline-2(1h)-one derivatives as antibacterial agents
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A series of chalcone derivatives and arylidene analogues derived from 3-acetyl coumarin were synthesized. The synthesized compounds were elucidated by spectroscopic analysis such as elemental analysis, infrared, 1H & 13C NMR and mass
- Alotaibi, Saad H.
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p. 1719 - 1727
(2020/07/30)
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- Hybrid Pharmacophoric Approach in the Design and Synthesis of Coumarin Linked Pyrazolinyl as Urease Inhibitors, Kinetic Mechanism and Molecular Docking
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The current research article reports the synthesis of coumarinyl pyrazolinyl thioamide derivatives and their biological activity as inhibitors of jack bean urease. The coumarinyl pyrazolinyl thioamides were synthesized by reacting thiosemicarbazide with n
- Saeed, Aamer,Mahesar, Parvez Ali,Channar, Pervaiz Ali,Larik, Fayaz Ali,Abbas, Qamar,Hassan, Mubashir,Raza, Hussain,Seo, Sung-Yum
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- Thiazolyl-pyrazole-biscoumarin synthesis and evaluation of their antibacterial and antioxidant activities
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Abstract: A series of novel 3-(2-oxo-2H-chromen-3-yl)-1-(4-(2-oxo-2H-chromen-3-yl)thiazol-2-yl)-5-aryl-1H-pyrazol-1-ium bromides have been prepared through a one-pot three-component cyclocondensation of various coumarin chalcones, thiosemicarbazide and 2-
- Mahmoodi, Nosrat O.,Ghodsi, Shahryar
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p. 661 - 678
(2017/02/10)
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- Synthesis and optical properties research of some novel trichromophore compounds containing coumarin, pyrazoline and naphthalimide groups
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A series of novel trichromophore compounds containing coumarin, pyrazoline and naphthalimide groups were synthesized and their properties were elucidated using absorption and fluorescence. In chloroform solution, their maximal absorption bands and the max
- Wu, Gongying,Zhao, Fang,Hu, Yang,Hu, Shengli
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- An Efficient One-Pot Synthesis of New Coumarin Derivatives as Potent Anticancer Agents under Microwave Irradiation
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An efficient and rapid synthesis of coumarin derivatives was accomplished via reactions of 3-(3-(4-methoxyphenyl)acryloyl)-2H-chromen-2-one (3) with different carbon nucleophiles such as ethyl acetoacetate, ethyl cyanoacetate, malononitrile, and ethyl benzoylacetate via conventional heating and microwave irradiation conditions and were used as source of pyran and pyridine derivatives bearing coumarin moiety 4–11. Compound 9a was condensed with different carbon electrophiles triethylorthoformate, phenylisothiocyanate, carbon disulfide, benzoylchloride, and acetylchloride that afforded the corresponding chromen derivatives 12–16. All the newly synthesized compounds were characterized by elemental and spectroscopic evidences. All of synthesized compounds were tested for in vitro cytotoxicity. The preliminary screening results showed that most of the compounds had moderate cytotoxic activity against HCT-116 and MCF-7 cell lines. Nevertheless, compound 10 exhibited potent activity against the two cell lines, which was comparable with the standard drug 5-fluorouracil.
- El-Naggar, Abeer M.,Hemdan, Magdy M.,Atta-Allah, Saad R.
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p. 3519 - 3526
(2017/11/21)
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- Synthesis and florescent properties of 5-aryl-3-(3-coumarinyl)-1-benzothiazolyl-2-pyrazolines
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A series of novel 5-Aryl-3-(3-coumarinyl)-1-benzothiazolyl-2-pyrazolines have been synthesized by the reaction of 3-coumarinyl chalcones with 2-hydrazinobenzothiazole in hot ethanol. And the structures of these new compounds have been characterized by 1HNMR, MS and elemental analysis. The fluorescence spectra of these compounds were also measured. All the compounds showed up strong green light emissions (λem: 557-570nm). The results showed that the absorption maxima of the compound vary from 415 to 420nm depending on the group bonded to pyrazolines rings.
- Liu, Manman,Liu, Qian,Zhang, Jian
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p. 301 - 306
(2016/08/20)
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- Bismuth triflate: A highly efficient catalyst for the synthesis of bio-active coumarin compounds via one-pot multi-component reaction
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A series of coumarin-chalcone hybrid compounds and coumarins linked to pyrazoline was synthesized in good yield and short time using a simple and efficient method. This method involved the one-pot reaction of salicylaldehyde, an α-ketoester and an aromatic aldehyde (in the case of the coumarin-chalcone derivatives) in addition to hydrazine hydrate (in the case of the pyrazolyl coumarins) in the presence of a catalytic amount of bismuth triflate [Bi(OTf)3, 5 mol%]. The synthesized compounds showed scavenging activity towards the free radical 2,2-diphenyl-1-picrylhydrazyl. All compounds were characterized using IR, 1H NMR and 13C NMR spectroscopy.
- El-Remaily, Mahmoud. Abd El Aleem. Ali. Ali.
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p. 1124 - 1130
(2015/07/07)
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- Cu(II) and Ni(II) complexes of coumarin derivatives with fourth generation flouroquinolone: Synthesis, characterization, microbicidal and antioxidant assay
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New Cu(II) and Ni(II) complexes of acetyl coumarin derivatives with gatifloxacin were synthesized. Characterization of the complexes was carried out by elemental analysis, FT-IR, FAB-MS, electronic spectra and magnetic measurement alongwith thermo gravimetric studies. Thermal study reveals the absence of coordinated water molecule in case of Cu(II) complexes. All the Cu(II) complexes were found more potent antibacterial activity compared to Ni(II) complexes. The antituberculosis data have shown that copper conjugation may be advantageous in designing highly effective drugs for antitubercular therapy. These complexes were also found to be potent antioxidizing agents comprising radical scavenging capability and ferric reducing abilities. Springer Science+Business Media 2014.
- Patel, Jiten,Dholariya, Hitesh,Patel, Ketan,Bhatt, Jaimin,Patel, Kanuprasad
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p. 3714 - 3724
(2014/08/05)
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- Synthesis and characterization of some heteroaromatic derivatives of 3-but-2-enoyl-chromen-2-one and their potential as anti-inflammatory agents
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A novel series of chromen-2-ones containing pyrazole, isoxazole, oxazine, and thiazine substitutions have been synthesized by reacting 3-[3-(4-chloro-phenyl)-acryloyl]-chromen-2-one and 3-[3-(3-methoxy-phenyl)- acryloyl]-chromen-2-one with various cyclizing agents such as hydrazine, phenylhydrazine, urea, and thiourea. The structures of all the synthesized compounds were confirmed by the use of IR, 1H-NMR, mass spectroscopy, and elemental analysis data. All the newly synthesized compounds were evaluated for their anti-inflammatory activity at a dose of 100 mg/kg body weight in carrageenan-induced rat paw edema model. The entire series of the compounds exhibited moderate to good anti-inflammatory activity, with the percentage inhibition of edema formation ranging from 39.99 to 63.15 against the reference drug ibuprofen (100 mg/kg) that showed 78.96% inhibition at the third hour. Compounds 3a, 3c, and 3d showed good inhibitory activity, whereas compounds 3b, 3e, 3f, and 3j showed moderate inhibitory activity at the third hour.
- Dixit, Priyanka,Tripathi, Avinash C.,Saraf, Shailendra K.
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p. 1431 - 1436
(2014/01/06)
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- Analgesic study of novel pyrimidine derivatives linked with coumarin moiety
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A novel series of 2-amino-4-(coumarin-3-yl)-6-substituted phenyl pyrimidines (5a-h) were synthesized from 3-acetylcoumarin (3). The structures of the synthesized compounds were elucidated by I.R., 1H NMR, 13C NMR, and Mass spectroscopic techniques. The synthesized compounds were screened for in vivo analgesic activities at a dose of 20 mg/kg body weight (b.w). Among them, compounds 5b and 5h exhibited significant analgesic activity comparable with control as well as standard drug diclofenac sodium using acetic acid-induced writhing model. Springer Science+Business Media, LLC 2011.
- Gupta, Jitendra Kumar,Sharma, Pramod K.,Dudhe, Rupesh,Chaudhary, Anshu,Singh, Avnesh,Verma,Mondal, Sambhu C.,Yadav, Rakesh Kumar,Kashyap, Shivjee
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p. 1625 - 1632
(2012/11/07)
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- Spectral, thermal, biological and multi-heating rate kinetic properties of Cu(II) complexes containing N2O2 donor ligands: 1,10-phenanthroline and acyl coumarins
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A series of newly synthesized coumarin-based mixed-ligand copper complexes with 1,10-phenanthroline (Ph) were investigated by means of thermogravimetry, differential thermogravimetry, differential scanning calorimetry (DSC), electronic spectra and magneti
- Patel, Jiten C.,Dholariya, Hitesh R.,Patel, Ketan S.,Patel, Kanuprasad D.
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p. 604 - 613
(2013/01/15)
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- Microwave-assisted synthesis and evaluation of antimicrobial activity of 3-{3-(s-aryl and s-heteroaromatic)acryloyl}-2H-chromen-2-one derivatives
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(Chemical Equation Presented) The exploration of potential utilization of microwaves as an energy source for heterocyclic synthesis was herein investigated using condensation of 3-acetylcoumarin (1) with aromatic and heteroaromatic aldehydes to afford the
- Ajani, Olayinka O.,Nwinyi, Obinna C.
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experimental part
p. 179 - 187
(2010/04/24)
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- Synthesis and pharmacological evaluation of a novel series of 5-(substituted)aryl-3-(3-coumarinyl)-1-phenyl-2-pyrazolines as novel anti-inflammatory and analgesic agents
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A novel series of 5-(substituted)aryl-3-(3-coumarinyl)-1-phenyl-2-pyrazolines (3a-l) were synthesized by reacting various substituted 3-aryl-1-(3-coumarinyl)propan-1-ones (2a-l) with phenylhydrazine in the presence of hot pyridine. Structures of all new s
- Khode, Suresh,Maddi, Veeresh,Aragade, Prashant,Palkar, Mahesh,Ronad, Pradeep Kumar,Mamledesai, Shivalingarao,Thippeswamy,Satyanarayana
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experimental part
p. 1682 - 1688
(2009/06/20)
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- Synthesis of some new 3-cummamoyl counarin oximes and related cyclisation products derived from 3-acetyl coumarin
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3-Acetylcoumarin 1 reacts with aldehydes to form corresponding 3-cummamoyl counarin 2a-g. Oximation of 2a-g with hydroxylamine hydrochloride in ethanol and (or) isopropanol aqueous solution give new 3-[1-oxo-3-(substituted-phenyl)]-2- propenyl-2H-1-benzop
- Ji,Hu,Hua,Hu
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p. 1223 - 1225
(2007/10/03)
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- ACYLPHOSPHONIUM COMPOUNDS OF COUMARIN
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The reaction of 3-(ω-bromoacetyl)coumarin with triphenylphosphine gives 3-coumarinocarbomethyltriphenylphosphonium bromide.The corresponding phoshorylide reacts readily with aldehydes to form coumarin analogs of chalcones.The acetylphosphonium salt and th
- Yagodinets, P. I.,Skripskaya, O. V.,Chernyuk, I. N.,Shevchuk, M. I.
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p. 1714 - 1719
(2007/10/02)
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