- Synthesis, photophysical and electrophosphorescent properties of fluorene-based platinum(II) complexes
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A series of platinum(II) complexes bearing tridentate cyclometalated C^N^N (C^N^N=6-phenyl-2,2'-bipyridine and π-extended R-C^N^N=3-[6'-(naphthalen-2''- yl)pyridin-2'-yl]isoquinoline) ligands with fluorene units have been synthesised and their photophysic
- Yuen, Mai-Yan,Kui, Steven C. F.,Low, Kam-Hung,Kwok, Chi-Chung,Chui, Stephen Sin-Yin,Ma, Chun-Wah,Zhu, Nianyong,Che, Chi-Ming
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supporting information; experimental part
p. 14131 - 14141
(2011/02/23)
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- Syntheses of acetylquinolines and acetylisoquinolines via palladium-catalyzed coupling reactions
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Acetylquinolines and acetylisoquinolines were obtained from the corresponding chloro-, bromo- or trifluoromethylsulfonyloxy-heteroaromatics via four different palladium-catalyzed coupling reactions: (i) Stille coupling with tri(n-butyl)-1-ethoxyvinylstannane; (ii) Negishi coupling with 1-ethoxyvinylzinc chloride; (iii) cross-coupling with tri(1-ethoxyvinyl)indium; (iv) Heck arylation of n-butyl vinyl ether.
- Legros, Jean-Yves,Primault, Ga?lle,Fiaud, Jean-Claude
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p. 2507 - 2514
(2007/10/03)
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- Homochiral isoquinolines by lipase-catalysed resolution and their diastereoselective functionalisation
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Kinetic resolution of racemic isoquinoline alcohols and acetates has been successfully accomplished using lipases as chiral catalysts. The diastereoselective functionalisation of the isoquinoline moiety through the addition of C-nucleophiles to O-protected alcohol 9a in the presence of phenyl chloroformate has been carried out and dihydroquinolyl alcohol derivatives with high diastereomeric excess have been prepared.
- Guanti, Giuseppe,Riva, Renata
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p. 1185 - 1200
(2007/10/03)
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- Electrochemical and spectroscopic properties of cyclometallated and non- cyclometallated ruthenium(II) complexes containing sterically hindering ligands of the phenanthroline and terpyridine families
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Two series of cyclometallated and noncyclometallated ruthenium(II) complexes incorporating mono- or disubstituted 1,10-phenanthroline- and 2,2':6',2''-terpyridine-type ligands have been synthesized and characterized. An X-ray crystal structure for one of the complexes, Ru(ttpy)(mapH)(Cl)(PF6), has been obtained (mapH = 2-p-anisyl-1,10- phenanthroline; ttpy = 4'-tolyl-2,2':6',2''-terpyridine). Distinct electrochemical and photophysical properties have been observed for the two series: a remarkable feature is the observation of relatively long-lived MLCT excited states (from 70 to 106 ns at room temperature in CH3CN) for three of the cyclometallated complexes. A discussion is given on the role of factors like sigma donation by the cyclometallating ligands, interligand steric hindrance and interligand π-π interactions that affect the electrochemical and spectroscopic properties.
- Barigelletti, Francesco,Ventura, Barbara,Collin, Jean-Paul,Kayhanian, Robert,Gavi?a, Pablo,Sauvage, Jean-Pierre
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p. 113 - 119
(2007/10/03)
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- Electrophilic activation of acetyl-substituted heteroaromatic compounds
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The chemistry of acetyl-substituted pyridines, thiazoles, quinoline, isoquinolines, and pyrazine (1-9 and 28) has been studied. These heteroarenes (1-8) condense with benzene in good yields (74-96%) in the Bronsted superacid, CF3SO3H (triflic acid). In these acid-catalyzed hydroxyalkylation reactions, compounds 1-8 are significantly more reactive than acetophenone. It is proposed that compounds 1-8 readily form dicationic electrophiles in triflic acid.
- Klumpp,Garza,Sanchez Jr.,Lau,De Leon
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p. 8997 - 9000
(2007/10/03)
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- Alpha-substituted pyrimidine-thioalkyl and alkylether compounds as inhibitors of viral reverse transcriptase
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The subject invention relates to pyrimidine-thioalkyl and alkylether compounds of Formula (I) and pyrimidine-thioalkyl and alkylethers of Formula (IA), namely the compounds of Formula (I) where R 4 is selected from the group consisitng of --H or --NR 15 R 16 where R 15 is --H and R 16 is --H, C 1 -C 6 alkyl, NH 2 or R 15 and R 16 taken together with the --N form 1-pyrrolidino, 1-morpholino or 1-piperidino; and R 6 is selected from the group consisting of --H, or halo (preferably --Cl); with the overall proviso that R 4 and R 6 are not both --H. The compounds of Formula (IA) are useful in the treatment of individuals who are HIV positive being inhibitors of viral reverse transcriptase. STR1
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- Propenoic acid derivatives useful as fungicides
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A fungicidal compound of formula (I): STR1 wherein A is hydrogen, halogen, hydroxy, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, C1-4 alkylcarbonyl, C1-4 alkoxycarbonyl, phenoxy, nitro or cyano; and one of R1 and R2 is optionally substituted isoquinoline while the other is hydrogen, C1-4 alkyl, C1-4 haloalkyl, halogen or cyano.
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- Fused azolium salts XVIII [1]. Synthesis and reactivity of a novel fused heteroaromatic system : [1,2,3]triazolo[1,5-b]isoquinolinium salts
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Oxidative cyclization of 3-isoquinolyl ketone hydrazones afforded the novel tricyclic heteroaromatic [1,2,3]triazolo[1,5-b]isoquinolinium salts. The reactivity of the ring system towards nucleophiles proved to be regioselective. Secondary amines induced r
- Beres, Mariann,Hajos, Gyoergy,Riedl, Zsuzsanna,Timari, Geza,Messmer, Andras
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p. 897 - 908
(2007/10/03)
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- Nouvelle voie de synthese d'isoidindolones et d'isoquinoleines par condensation d'iminophosphoranes avec l'ortho-phthalaldehyde: reactions, mecanismes et etude structurale
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The condensation of various iminophosphoranes with o-phthalaldehyde led directly to N-substituted isoindoline-1-ones and 3-acylisoquinolines.Three different mechanisms, depending on the nature of the iminophosphorane and reaction conditions, are proposed.All the compounds have been fully characterized, particularly by one- and two-dimensional nuclear magnetic resonance spectroscopy.
- Aubert, Thierry,Farnier, Michel,Guilard, Roger
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p. 842 - 851
(2007/10/02)
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- A NEW VERSATILE SYNTHESIS OF ISOQUINOLINES BY CONDENSATION OF IMINOPHOSPHORANES WITH o-PHTHALALDEHYDE
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The 3-isoquinolyl ketones (2a-d) are obtained by a one-pot procedure involving condensation of o-phthalaldehyde with iminophosphoranes (1a-d) generated in situ from the corresponding organic azides.
- Aubert, T.,Farnier, M.,Hanquet, B.,Guilard, R.
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p. 1831 - 1838
(2007/10/02)
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- 2-acetylpyridine thiosemicarbazones. 12. Derivatives of 3-acetylisoquinoline as potential antimalarial agents
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A series of 3-acetylisoquinoline thiosemicarbazones and their related thiosemicarbazides was prepared for evaluation as potential antimalarial agents. The former were synthesized by the reaction of 3-acetylisoquinoline with methyl hydrazinecarbodithioate to give methyl 3-[1-(3-isoquinolinyl)ethylidene]hydrazinecarbodithioate, IV. Displacement of the S-methyl group of this intermediate by the requisite amines gave 3-acetylisoquinoline thiosemicarbazones, V. The corresponding thiosemicarbazides, in which the azomethine bond was reduced, were prepared by the reduction of IV with sodium borohydride to give methyl 3-[1-(3-isoquinolinyl)ethyl]hydrazinecarbodithioate, VI. Reaction of this dithioester with amines gave 1-[1-(3-isoquinolinyl)ethyl-3-thiosemicarbazides, VII. The antimalarial properties of series V and VII were evaluated in mice infected with Plasmodium berghei. Significant curative activity could be observed at doses as low as 40 mg/kg for 3 of 10 compounds in series V and at 160 mg/kg for 3 of 11 compounds in series VII.
- Klayman,Acton,Scovill
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