Modulation of Wnt signaling through inhibition of secreted frizzled-related protein i (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides
The diphenylsulfonyl sulfonamide scaffold represented by 1 (WAY-316606) are small molecule inhibitors of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt. Modulators of the Wnt pathway have been proposed as anabolic a
Moore, William J.,Kern, Jeffrey C.,Bhat, Ramesh,Commons, Thomas J.,Fukayama, Shoichi,Goljer, Igor,Krishnamurthy, Girija,Magolda, Ronald L.,Nogle, Lisa,Pitts, Keith,Stauffer, Barb,Trybulski, Eugene J.,Welmaker, Gregory S.,Wilson, Matthew,Bodine, Peter V. N.
experimental part
p. 105 - 116
(2009/08/07)
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