- Synthesis of ethyl nicotinate-5-boronic acid pinacol ester and its application toward Suzuki coupling
-
A method for the synthesis and isolation of pure ethyl nicotinate-5-boronic acid pinacol ester has been described. This boronate ester was used to prepare C2-C5 heteroarylnicotinates in good yields. Copyright Taylor & Francis Group, LLC.
- Leblanc, Yves,Cerat, Pascal
-
-
Read Online
- Regioselective conversion of arenes to N-aryl-1,2,3-triazoles Using C-H Borylation
-
A one-pot protocol for the synthesis of N-aryl 1,2,3-triazoles from arenes by an iridium-catalyzed C-H borylation/copper catalyzed azidation/click sequence is described. 1mol % of Cu(OTf)2 was found to efficiently catalyze both the azidation and the click reaction. The applicability of this method is demonstrated by the late-stage chemoselective installation of 1,2,3-triazole moiety into unactivated molecules of pharmaceutical importance.
- Srinivasan, Rajavel,Coyne, Anthony G.,Abell, Chris
-
supporting information
p. 11680 - 11684
(2014/10/15)
-
- PYRROLOTRIAZINES AS POTASSIUM ION CHANNEL INHIBITORS
-
A compound of formula (I) wherein A, R1, R3, and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment of arrhythmia, maintaining normal sinus rhythm, IKur-associated disorders, and other disorders mediated by ion channel function.
- -
-
Page/Page column
(2014/09/29)
-
- PHTHALAZINES AS POTASSIUM ION CHANNEL INHIBITORS
-
A compound of formula (I), wherein A, R1, R3, and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.
- -
-
Page/Page column 58
(2014/09/29)
-
- PYRROLOPYRIDAZINES AS POTASSIUM ION CHANNEL INHIBITORS
-
A compound of formula (I) wherein A, R1, R3, and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.
- -
-
Page/Page column 49
(2014/09/29)
-
- PI3 KINASE/mTOR DUAL INHIBITOR
-
The present invention provides an imidazo[4,5-c]quinolin-2-one compound, or a pharmaceutically acceptable salt thereof, that inhibits both PI3K and mTOR and, therefore, is useful in the treatment of cancer.
- -
-
Page/Page column 5
(2012/07/28)
-