Multicomponent synthesis of dihydrobenzoxazepinones by coupling Ugi and Mitsunobu reactions
Various dihydrobenzo[f][1,4]oxazepin-5-ones have been convergently prepared in 2-3 steps by coupling Ugi and Mitsunobu reactions. Two alternative methodologies were used: in the first one the Ugi condensation was followed by a Mitsunobu cyclization (2 ste