- Syntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABAB receptors
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The optimization of GS39783 into potent, selective, and safe positive allosteric modulators of GABAB receptors is presented.
- Guery, Sebastien,Floersheim, Philipp,Kaupmann, Klemens,Froestl, Wolfgang
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p. 6206 - 6211
(2008/04/03)
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- PYRIMIDINE DERIVATIVES FOR THE TREATMENT OP GABA B MEDIATED NERVOUS SYSTEM DISORDERS
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The invention relates to novel heterocyclic compounds of the formula (I) in free base form or in acid addition salt form, in which R1, R2, R3, R4 and A are as defined in the specification, to their preparation, to their use as medicaments for the treatment of certain nervous system disorders and to medicaments comprising them.
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Page/Page column 54-55
(2010/11/25)
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