A new approach to the synthesis of peptidomimetic renin inhibitors: Palladium-catalyzed asymmetric allylation of acyclic alkyl aryl ketones
A new approach to the synthesis of Tekturna, a recently marketed drug for hypertension, takes advantage of a modified protocol of the Stoltz palladium-catalyzed asymmetric allylation with a t-BuPHOX ligand for the synthesis of allylated acyclic alkyl aryl
Hanessian, Stephen,Chénard, Etienne
supporting information; experimental part
p. 3222 - 3225
(2012/08/08)
AMIDE INHIBITORS OF RENIN
The present invention relates to new amide inhibitors of renin, pharmaceutical compositions thereof, and methods of use thereof
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(2010/06/13)
NEW PYROCATECHIN DERIVATIVES
Pyrocatechin derivatives of formula I wherein R illustrates a group of formulae Ia, Ib, Ic or Id R1 is 4-halogen-but-2-enyl, R2 is lower alkyl or cycloalkyl, R3 is lower alkoxy and R4 is lower alkoxy lower alkox
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Page/Page column 18
(2008/06/13)
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