- Diastereoselective solid-phase radical addition to oxime ether anchored to polymer support
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Stereocontrol in radical reactions of oxime ether anchored to polymer support was studied. Highly diastereoselective solid-phase radical reaction was achieved by using triethylborane and diethylzinc as a radical initiator at low reaction temperature, providing a novel method for the synthesis of the α-amino acid derivatives with excellent diastereoselectivities.
- Miyabe, Hideto,Konishi, Chihiro,Naito, Takeaki
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- BUPRENORPHINE ANALOGS
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The present invention is directed to Buprenorphine Analog compounds of the Formula (I), Formula (IA) or Formula (IB) shown below, wherein R1, R2, R8, R3a, R3b, G, X, Z and Y are as defined herein. Compounds of the Invention are useful for treating pain, constipation, and other conditions modulated by activity of opioid and ORL-1 receptors.
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Page/Page column 517; 518
(2012/04/10)
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- PYRIDONE COMPOUND
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An active ingredient is a compound represented by the general formula [I]: [wherein R1 and R2 represent a lower alkyl group, a C3-6 cycloalkyl group or the like, X1 and X2 represent methine, an Ar-Ys
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Page/Page column 39
(2010/11/30)
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