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929095-18-1

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Regioselective synthesis of benzimidazole thiophene inhibitors of polo-like kinase 1
A regioselective synthesis of novel 1-(2-thienyl)-benzimidazole inhibitors of polo-like kinase 1 is described. Amination of substituted 2-iodo or -bromo nitrobenzenes with a 2-aminothiophene derivative catalyzed by Pd2dba3 and XANTPH
Hornberger, Keith R.,Badiang, Jennifer G.,Salovich, James M.,Kuntz, Kevin W.,Emmitte, Kyle A.,Cheung, Mui
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p. 6348 - 6351
(2009/04/07)

PROCESSES FOR PREPARING BENZIMIDAZOLE THIOPHENES
A process for preparing benzimidazole thiophenes including 5-{6-[(4-methylpiperazin-1-yl)methyl]-1H-benzimidazol-1-yl}-3-{(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy}thiophene-2-carboxamide.
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Page/Page column 34-35

(2009/03/07)

BENZIMIDAZOLE THIOPHENE COMPOUNDS
The present invention provides benzimidazole thiophene compounds pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
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Page/Page column 59

(2010/11/26)

REGIOSELECTIVE PROCESS FOR PREPARING BENZIMIDAZOLE THIOPHENES
The present invention provides a process for preparing benzimidazole thiophene compounds of formula I. Intermediates used in the process are also claimed.
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Page/Page column 152; 156

(2010/11/26)

More Articles about upstream products of 929095-18-1

929095-51-2
methyl 5-{6-[(4-methyl-1-piperazinyl)methyl]-1H-benzimidazol-1-yl}-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)-2-thiophenecarboxylate

Chemical Properties

Appearance/Colour :White to gray solid
Boiling Point: 658 °C at 760 mmHg
Flash Point:351.7 °C
Density: 1.39 g/cm³
Solubility:Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
Storage Temp.:Hygroscopic, -20°C Freezer, Under inert atmosphere
PKA: 15.16±0.50(Predicted)
PSA: 104.86000
LogP: 5.66820

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