- Synthesis method of 5-chlorine-2-phenoxyaniline and Beta molecular sieve used in synthesis method
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The invention discloses a synthesis method of 5-chlorine-2-phenoxyaniline. The synthesis method comprises the following steps: 1) heating 2, 5-dichloronitrobenzene to be melted in a solvent-free state, adding a condensation phase transfer catalyst into the melted 2, 5-dichloronitrobenzene, then adding sodium hydroxide and phenol into the mixture and performing a reaction at the temperature of 60-130 DEG C for 3-5h; 2) cooling a reaction product, adding a solvent, hydrazine hydrate and a Beta molecular sieve reduction catalyst into the reaction product, heating the mixture to backflow and performing a reduction reaction; 3) after a backflow reaction in step 2) is ended, performing filtration to obtain the Beta molecular sieve reduction catalyst and filtrate, distilling the filtrate to obtain alcohol in the solvent, cooling to 15-20 DEG C, stirring the mixture for 3-5h, performing separation by crystallization and performing filtration, so as to obtain the 5-chlorine-2-phenoxyaniline asa filter cake. The 5-chlorine-2-phenoxyaniline is synthesized by adopting the method disclosed by the invention, the technical advantages of having no wastes and saving energy are achieved.
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Paragraph 0058; 0059; 0061; 0065
(2019/01/08)
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- A 2 - amino - 4 - chlorodisilanes diphenyl ether (by machine translation)
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The invention discloses a 2 - amino - 4 - chlorodisilanes ether of preparation method, comprises the following steps: the 2 - nitro - 4 - chlorodisilanes ether, six water of ferric chloride and active carbon dispersed in ethanol, then adding alkali to adjust the pH to 7 - 9, under the heating condition [...] drip water reduction reaction, the reaction after the end of the, through after-processed to obtain the 2 - amino - 4 - chlorodisilanes ether. The preparation method of mild reaction conditions, easy-to-control, the reaction apparatus is simple, the catalyst and the solvent can be recycled repeatedly, friendly to the environment, the product quality is stable, the purity is good, high yield, facilitates large scale production. (by machine translation)
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Paragraph 0027; 0028
(2017/05/27)
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- ANTI-VIRAL COMPOUNDS
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Compounds effective in inhibiting replication of Hepatitis C virus ( HCV ) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, coformulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
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Page/Page column 81-82
(2008/12/08)
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- Synthesis and evaluation of antipsychotic activity of 11-(4-aryl-1- piperazinyl)-dibenz [b, f][1,4] oxazepines and their 8-chloro analogues
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Atypical drugs reduce positive and negative symptoms of schizophrenia, without inducing EPS, but they exert other undesirable side effects. We have gone for synthesis of novel derivatives of Loxapine which are devoid of catalepsy and have decreased metabolic demethylation which is the prominent factor for bioavailability of the drug. While doing so we have also been successful in retaining the antipsychotic activity of the drug. Condensation of 8,11-dichlorodibenzoxazepine and 11-chlorodibenzoxazepine with 1-aryl piperazines was carried to give 8-chloro-11-(4-aryl-1-piperazinyl)-dibenz[b,f] [1,4]oxazepines and 11-(4-aryl-1-piperazinyl)-dibenz[b,f][1,4]oxazepines respectively. These derivatives were found as active as Clozapine.
- Wagh,Patil,Jain,Harak,Wagh
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p. 165 - 172
(2008/02/12)
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- New spermine and spermidine derivatives as potent inhibitors of trypanosoma cruzi trypanothione reductase
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Several spermine and spermidine derivatives containing 2-amino diphenylsulfide substituents were prepared and tested for their inhibiting effects on Trypanosoma cruzi trypanothione reductase. IC50 values were assessed between 0.3 and 3 μM. Compound 32 (K(i) = 0.4 μM) is the most potent TR inhibitor described so far.
- Bonnet, Beatrice,Soullez, David,Davioud-Charvet, Elisabeth,Landry, Valerie,Horvath, Dragos,Sergheraert, Christian
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p. 1249 - 1256
(2007/10/03)
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- 2-, 3-, 5-, 8-, 10- AND/OR 11-SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATING PAIN
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The present invention provides substituted dibenzoxazepine compounds of Formula I: STR1 which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.
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