- (R, S) - 2 - [[ 5 - (9- [...] carbonyl amino) dibenzo [a, d] cyclohepta-2-yl] oxy] method for the preparation of acetic acid (by machine translation)
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The invention relates to a preparation method of Ramage linker and mainly solves problems of long processes, complex post-treatment, much waste water, waste gas and solid waste, and high cost in a conventional synthetic method. The preparation method incl
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Paragraph 0027; 0044-0045; 0050-0051; 0056-0057
(2020/05/05)
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- (R, S)-2-[ [5-(9- [...] carbonyl amino) dibenzo [A, D] cyclohepta-2-yl] oxy] acetic acid synthesis process (by machine translation)
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The invention relates to a (R, S)-2-[ [5-(9- [...] carbonyl amino) dibenzo [A, D] cyclohepta-2-yl] oxy] acetic acid synthesis process, comprising the following steps: step one, O-carboxybenzaldehyde and Intergovernmental methoxylphenylboronic acetic acid in anhydrous sodium acetate under the catalysis of the reaction to obtain 2-(3-methoxy-vinyl) benzoic acid, Pd-C under the catalysis of the hydrogen reduction reaction-; step two, and SOCl 2 reaction to obtain 2-methoxy -10, 11-dihydro -5H-dibenzo [a, d] cycloheptene-5-one, then anhydrous AlCl 3 catalytic reflux reaction; step three, the return reaction of the intermediate product and bromine second grade acid benzyl ester for reaction; step four, the reduction reaction of the hydrogen gas, and then with Fmoc-NH 2 for reaction, to obtain. This invention, through optimization of the catalyst, is obviously improved the overall yield, effectively reducing the cost, is suitable for industrial mass synthesis application. (by machine translation)
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Paragraph 0040; 0042
(2017/09/19)
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- Design of a versatile linker for solid phase peptide synthesis: Synthesis of C-terminal primary/seconary amides and hydrazides
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An efficient, versatile linker for solid phase peptide synthesis, based upon the dibenzocyclohepta-1,4-diene system, has been developed for the synthesis of C-terminal primary/secondary amides and hydrazides.
- Ramage,Irving,McInnes
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p. 6599 - 6602
(2007/10/02)
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