- ANTIDIABETIC BICYCLIC COMPOUNDS
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Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-co
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Page/Page column 59
(2019/06/09)
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- SERINE/THREONINE KINASE INHIBITORS
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Compounds having the formula I wherein R1, R2, R3, R4, R5, Ra, Rb, Rc, Rd, Re, n, r, s and t are as defined herein and which compounds are inhibitors of PAK1. Also disclosed are compositions and methods for treating cancer and hyperproliferative disorders.
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Paragraph 0325; 0322
(2015/02/19)
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- A general and efficient route to 6-methyl-pyrazin-2-yl-amines: Alkylation of 2,6-dichloropyrazine via malonate derivatives
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(Chemical Equation Presented) We have developed a convenient two-stage process for the synthesis of 6-methylpyrazine-2-yl-amines from commercially available materials. The procedure involves the synthesis of (6-chloro-pyrazin-2-yl)-acetic acid via arylati
- Colbon, Paul J. J.,Foster, Alison C.,Giles, Melvyn E.,Patel, Zakariya,Singleton, John T.
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experimental part
p. 1451 - 1456
(2009/04/07)
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- NOVEL PROCESS FOR THE PREPARATION OF 6-METHYL-PYRAZIN-2-YLAMINE
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A new process for the preparation of 6-methyl-pyrazin-2- ylamine is described. The process involves reacting 2,6- dichloropyrazine with a dialkylmalonate followed by subsequent decarboxylation rendering a new compound, 6-chloro-pyrazin-2- yl -'acetic acid. Further decarboxylation and amination renders the desired product.
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Page/Page column 4-5
(2008/06/13)
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- NOVEL N-PYRAZINIL-PHENYLSULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS FOR USE IN THE TREATMENT OF ASTHMA
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The invention provides a compound of formula (I), wherein R1, R2 and R3 are as defined in the specification, pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions, and their use in therapy.
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Page/Page column 28-29
(2010/11/26)
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