- Rapid synthesis and lipase inhibition activity of some new benzimidazole and perimidine derivatives
-
This study presents a synthesis of new series of some benzimidazole, bisbenzimidazole and perimidine derivatives via microwave technique, which, leads to the good product yields and short reaction times. The structure of newly synthesized compounds was confirmed by 1H NMR and 13C NMR spectra. These compounds were screened for their lipase inhibition activity. Then, all compounds were evaluated with regard to pancreatic lipase activity, and some of the 2-substituted perimidines, bisperimidine and bisbenzimidazole derivatives showed lipase inhibition at various concentrations.
- Mente?e,Y?lmaz,Karaali,ülker,Kahveci
-
p. 336 - 342
(2014/06/09)
-
- Synthesis and antiproliferative activity of imidazole and imidazoline analogs for melanoma
-
We have previously reported substituted 2-aryl-thiazolidine-4-carboxylic acid amides as potent and selective antiproliferative agents for melanoma. To understand the importance of the thiazolidine ring and to reduce potential complications associated with the two chiral centers, we designed and synthesized sets of new analogs by modifying this ring. These new analogs were tested in two melanoma cell lines and fibroblast cells (negative controls). Compared with the older analogs containing the thiazolidine ring, these new analogs have lower potency in general, but some of these analogs still have very good selectivity. These structure-activity studies indicated that the thiazolidine ring is very critical for the activity for these series of compounds.
- Chen, Jianjun,Wang, Zhao,Lu, Yan,Dalton, James T.,Miller, Duane D.,Li, Wei
-
body text
p. 3183 - 3187
(2009/04/11)
-
- Synthesis and choleretic activity of 3-[2-(3-R', 4-R'', 5-R'''-benzyl)-5- R-benzimidazol-1-yl]-butanoic acids
-
On the ground of the evidentiated choleretic activity of 3-[2- benzylbenzimidazol-1-yl]butanoic acid, 28 new acids were prepared in order to evaluate the influence of suitable substitutions in either C5 of heteroring or C3', C4', C5' of benzyl group in po
- Grella,Paglietti,Sparatore,Satta,Manca,Peana
-
-
- Synthesis and reactions of 2-amino-7,8-dimethoxy-1H-3-benzazepines. Competitive formation of 2-amino-1H-3-benzazepines VS. 2-benzylimidazoles
-
A short synthesis of 2-amino-7,8-dimethoxy-1H-3-benzazepine (1a) from 3,4-dimethoxyphenylacetonitrile is reported. The synthesis of several other 2-amino-1H-3-benzazepines 1 is also discussed. Conditions which favor the formation of 1 versus the formation
- Robey,Copley-Merriman,Phelps
-
p. 779 - 783
(2007/10/02)
-