A novel method for the synthesis of aryl trihalomethyl sulfones and their derivatization: The search for new sulfone fungicides
A novel method for the preparation of bioactive aryl trihalomethyl sulfones is reported. An iodination reaction with iodine bromide is applied for the synthesis of difluoroiodomethyl aryl sulfones. A series of difluoroiodomethylsulfonyl group bearing derivatives is afforded, including nitroanilines and benzimidazoles. Biological studies show high fungicidal activity for a number of the synthesized sulfones.
Korzyński, Maciej D.,Borys, Krzysztof M.,Bia?ek, Justyna,Ochal, Zbigniew
Sulfone derivatives enter the cytoplasm of Candida albicans sessile cells
Since our study showed that sulfone derivatives’ action mode creates a lesser risk of inducing widespread resistance among Candida spp., we continued verifying sulfones’ antifungal activity using the following newly synthesized derivatives: bromodichlorom
Aryliododifluoromethylsulfides, sulfoxides and sulfones: The first optically active compounds with polyfluoroalkyliodo groups
Aryliododifluoromethyl sulfoxides, which were transformed in aryliododifluoromethyl sulfides and sulfones, were obtained by the coupling of mercury salts of arylsulfoxydifluoromethylacetic acids with iodine.
Yagupolskii, Lev M.,Matsnev, Andrej V.
p. 132 - 134
(2007/10/03)
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