Straightforward access to simplified sphingosine-1-phosphate analogues
A straightforward approach for the synthesis of a new series of amino phosphates structurally related to sphingosine-1-phosphate is described. The commercial availability of the required starting building blocks, the reduced number of steps, and the ease
Grijalvo, Santiago,Llebaria, Amadeu,Delgado, Antonio
p. 2737 - 2751
(2008/02/12)
Design, synthesis and activity as acid ceramidase inhibitors of 2-oxooctanoyl and N-oleoylethanolamine analogues
The synthesis of novel N-acylethanolamines and their use as inhibitors of the aCDase is reported here. The compounds are either 2-oxooctanamides or oleamides of sphingosine analogs featuring a 3-hydroxy-4,5-hexadecenyl tail replaced by ether or thioether