- Preparation method of 4-halogenated-3-fluorotoluene
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The invention belongs to the field of organic synthesis, and particularly relates to a preparation method of 4-halogenated -3-fluorotoluene. The preparation reaction of 4-halogenated -3-fluorotolueneshown as a formula (I) is shown in the specification. According to the method, halogenation reaction is conducted on 3-fluorotoluene serving as an initial raw material to obtain a halide, and hydrogenreduction is conducted to obtain a compound shown in the general formula (I), wherein X is chlorine or bromine. According to the method, 3-fluorotoluene is used as a raw material, and a target product is obtained through two-step reactions of halogenation and reduction. The reaction steps in the process are few; diazotization, nitrification and other reactions are avoided, and the reaction safetyis high.
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Paragraph 0046-0047; 0068-0069
(2021/03/31)
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- Synthesis of 3-Fluoro-2-substituted amino-5,12-dihydro-5-oxobenzoxazoloquinoline-6-carboxylic Acids Employing the Tandem Double Ring Closure Reaction of N-Acetyl-N-(2-hydroxyphenyl)anthranilic Acid as the Key Step
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A general synthetic method for the preparation of 5,12-dihydro-5-oxobenzoxazoloquinoline-6-carboxylic acids has been developed making use of the tandem double ring closure reaction of N-(2-hydroxyphenyl)anthranilic acid as the key step. 2-(4-Methylpiperazin-1-yl)-3-fluoro-5,12-dihydro-5-oxobenzoxazoloquinoline-6-carboxylic acid, an oxygen isostere of a potent antibacterial, A-57,207 was thus synthesized.
- Chung, Sang J.,Kim, Dong H.
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p. 12549 - 12562
(2007/10/02)
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