Synthesis and antiviral activity of some C2-, C4-, and C6-substituted pyrazolo[3,4-d]pyrimidine acyclonucleosides with the alkylating chains of ACV, HBG, and iso-DHPG
A useful route to obtain trisubstituted pyrazolo[3,4-d]pyrimidines 14-17 is described. Those later were coupled with the alkylating agents 18-20 as in ACV, HBG, and iso-DHPG to give, after deprotection, the desired acylonucleosides 33-44 . Almost all of t
Moukha-Chafiq, Omar,Taha, Mohamed,Lazrek, Hassan,Vasseur, Jean-Jacques,Clercq, Erik
p. 849 - 860
(2007/10/03)
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