Convenient and straightforward synthesis of ibrutinib labeled by carbon-13 isotope is reported. Isotopically labeled building block is introduced in the last step of reaction sequence affording sufficient isolated yield (7%) of [13C6]-ibrutinib calculated towards starting commercially available [13C6]-bromobenzene.
Kriegelstein, Michal,Hroch, Milo?,Marek, Ale?
p. 500 - 512
(2021/09/22)
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