- Synthesis of chloroesters by the reaction of ethers with acyl chlorides catalyzed by ZnO
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An efficient method for the synthesis of chloroesters by the reaction of ethers with acyl chlorides catalyzed by nano-ZnO under solvent-free condition at room temperature was described. The method is compatible with a range of ethers including tricyclic ethers, tetracyclic ethers, pentacyclic ethers and hexacyclic ethers and have afforded the products with moderate to good yields. The ZnO could be reused up to three times and the product yield after three cycles is 87%.
- Tang, Yuqi,Feng, Chengliang,Yang, Wanfeng,Ji, Min,Wang, Wei,Chen, Junqing
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- A process for preparing the silodosin intermediates
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The invention discloses a preparation method of a silodosin intermediate, wherein the structure of the silodosin intermediate is represented as the formula A. The preparation method, wherein indoline is employed as a start raw material, includes the reactions of Friedel-Crafts acylation, carbonyl reduction, Gabriel reaction and chiral resolution and the like. The preparation method is simple in operation, is low in cost, is high in yield, allows the product to purify easily and is stable in processes, and is suitable for industrial production. The invention also discloses a new intermediate compound which is related in the method.
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Paragraph 0102-0106
(2017/11/16)
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- Copper-catalyzed Csp3-O cross-coupling of unactivated alkyl halides with organic peroxides
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An efficient Cu-catalyzed Csp3-O coupling of peroxides with haloalkanes is described. High yields of products were achieved under mild conditions. Significantly, in addition to primary alkyl halides, secondary alkyl halogenated hydrocarbons could also be applied to this system. The new reaction system could tolerate a wide range of organic peroxides.
- Chen, Huan-Huan,Wang, Guang-Zu,Han, Jin,Xu, Meng-Yu,Zhao, Yong-Qiang,Xu, Hua-Jian
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p. 212 - 217
(2014/01/06)
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- Synthesis of esters from aldehydes or carboxylic acids with dichloromethane, dichloroethane or dichloropropane under mild conditions
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Dichloromethane (DCM) as a C1 source has been discovered: methylene diesters from DCM and carboxylic acids or aldehydes with TBHP in water were efficiently synthesized. The reactions proceed under mild conditions and afford both aliphatic and aromatic met
- Lin, Feng,Feng, Qiang,Cui, Xiuling,Song, Qiuling
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p. 20246 - 20253
(2013/11/06)
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- Cu-catalyzed esterification reaction via aerobic oxygenation and C-C bond cleavage: An approach to α-ketoesters
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The Cu-catalyzed novel aerobic oxidative esterification reaction of 1,3-diones for the synthesis of α-ketoesters has been developed. This method combines C-C σ-bond cleavage, dioxygen activation and oxidative C-H bond functionalization, as well as provides a practical, neutral, and mild synthetic approach to α-ketoesters which are important units in many biologically active compounds and useful precursors in a variety of functional group transformations. A plausible radical process is proposed on the basis of mechanistic studies.
- Zhang, Chun,Feng, Peng,Jiao, Ning
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supporting information
p. 15257 - 15262
(2013/11/06)
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- NOVEL PROCESS FOR THE SYNTHESIS OF INDOLINE DERIVATIVES
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The present invention provides an improved process for the synthesis of indoline intermidiate and its pharmaceutically acceptable derivatives, salts or solvates thereof, useful in the synthesis of α-1 adrenoceptor blockers such as silodosin.
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Page/Page column 29
(2012/10/18)
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- Acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase
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We report the discovery of novel uracil-based acyclic compounds as inhibitors of deoxyuridine 5′-triphosphate nucleotidohydrolase (dUTPase), an enzyme involved in nucleotide metabolism that has been identified as a promising target for the development of
- Nguyen, Corinne,Ruda, Gian Filippo,Schipani, Alessandro,Kasinathan, Ganasan,Leal, Isabel,Musso-Buendia, Alexander,Kaiser, Marcel,Brun, Reto,Ruiz-Pérez, Luis M.,Sahlberg, Britt-Louise,Johansson, Nils Gunnar,González-Pacanowska, Dolores,Gilbert, Ian H.
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p. 4183 - 4195
(2007/10/03)
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- Group 5 and group 6 metal halides as very efficient catalysts for acylative cleavage of ethers
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Group 5 and 6 metal chlorides such as MoCl5, WCl6, NbCl5 and TaCl5 were found as very efficient catalysts for acylative cleavage of the C-O bond of ethers. Compared with conventional Lewis acid catalysts such as ZnCl2, AlCl3, SnCl4 and TiCl4, group 5 and 6 metal chlorides showed better results in the catalytic C-O bond cleavage of dibutyl ether with benzoyl chloride.
- Guo, Qiaoxia,Miyaji, Taichi,Hara, Ryuichiro,Shen, Baojian,Takahashi, Tamotsu
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p. 7327 - 7334
(2007/10/03)
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- A new synthetic method for haloalkyl carboxylic esters from the radical ring cleavage of cyclic acetals with haloform
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A one-pot reaction of cyclic acetals with haloform catalyzed by AIBN(2,2'-azobisisobutyronitrile) provides a novel convenient way to prepare directly haloalkyl carboxylic esters in good yields.
- Hai-Xia, Lin,Liang-Heng, Xu,Nai-Ju, Huang
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p. 303 - 306
(2007/10/03)
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- Reaction of Epoxides with Chlorocarbonylated Compounds Catalyzed by Hexaalkylguanidinium Chloride
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Silica-supported guanidinium chloride (PBGSiCl) exhibits efficient chemo- and regiospecific catalytic activity in the ring opening of epoxides with various electrophiles.This reaction allows the preparation of β-chloro esters and β-chloro chloroformates in high yield under neutral conditions which offer product stability and ease of product isolation.
- Gros, P.,Perchec, P. Le,Senet, J. P.
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p. 4925 - 4930
(2007/10/02)
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- Reactions of 1,3-dioxolanes with Iodine Monochloride: Formation of Chlorohydrin Esters and Diol Monoesters
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2-Mono-substituted 1,3-dioxolanes are oxidised by iodine monochloride to the appropriate 2-substituted 1,3-dioxolan-2-ylium ions, whose stability is dependent upon the presence and nature of substituents on C-4 and C-5.Some dioxolanylium ions are labile and under the reaction conditions afford chlorohydrin esters, with inversion of configuration taking place at the ring carbon attacked by chloride.Others are stable under the reaction conditions and may be converted on aqueous workup to diol monoesters with retention of configuration at C-4 and C-5.The effect of substituents and reaction conditions on these competing reactions are described.The stereo- and regio-chemistry of both hydroxy- and chloro-ester formation was confirmed through NMR studies, which necessitated the prior detailed analysis of the 1H and 13C spectra associated with the acyloxy sidechains of the relevant esters.
- Glass, Beverley D.,Goosen, Andre,McCleland, Cedric W.
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p. 2175 - 2182
(2007/10/02)
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- Non-Catalyzed Cleavage Reactions of Ethers with Acyl Halides under High-Pressure Conditions
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Various cyclic and acyclic ethers are efficiently cleaved with acyl chlorides or bromides to give ω-chloro- or ω-bromoesters under high-pressure conditions.
- Kotsuki, Hiyoshizo,Ichikawa, Yoshikatsu,Nishizawa, Hitoshi
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p. 673 - 676
(2007/10/02)
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