- Photoinduced Deaminative Borylation of Unreactive Aromatic Amines Enhanced by CO2
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Herein, direct unreactive C-N borylation of aromatic amines by a photocatalyst was achieved. The C-N borylation of aromatic amines with bis(pinacolato)diboron (B2pin2) proceeded using a pyrene catalyst under light irradiation to afford desired borylated products and aminoborane as a byproduct. The yield of the borylated product improved under a CO2 atmosphere which probably reduced the inhibitory effect of aminoborane. Mechanistic studies suggested that the C-N bond cleavage and C-B bond formation proceeded via a concerted pathway.
- Shiozuka, Akira,Sekine, Kohei,Kuninobu, Yoichiro
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supporting information
p. 4774 - 4778
(2021/06/28)
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- Aromatic amine derivative organic electroluminescent material and device thereof
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The invention discloses an aromatic amine derivative organic electroluminescent material and a device thereof. The compound is an aromatic amine substituted pyrene compound, and a longer arylene group or heteroarylene group and other structures are introduced among one arylamine and pyrene to prolong the molecular length of the luminescent material. The compound can be used as a luminescent material in an organic electroluminescent device. These novel compounds provide better device performance, such as light emission efficiency and external quantum efficiency. An electroluminescent device and a compound formulation are also disclosed.
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Paragraph 0143; 0147-0149
(2021/09/29)
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- COMPOUND, COMPOSITION COMPRISING THE SAME, AND ORGANIC ELECTROLUMINESCENT ELEMENT COMPRISING THAT COMPOSITION
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PROBLEM TO BE SOLVED: To provide an organic electroluminescent element that is sufficient in performance (e.g., efficiency, lifespan) even when a hole transport layer is formed by a wet method. SOLUTION: The invention provides a compound represented by the formula (1) in the figure. In the formula, Ar1 represents an aromatic hydrocarbon; I represents an integer from 0 to 2 inclusive; G1 and G2 represent N, Si, or the like; L1 and L2 each represent a specific ring structure or the like; and A represents a specific structure including an aromatic group. SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT
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Paragraph 0224; 0239-0240
(2020/10/03)
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- COMPOUNDS FOR THE MODULATION OF PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9)
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The present disclosure relates to novel compounds capable of binding to PCSK9, thereby modulating PCSK9 biological activity. Also provided are compositions comprising these compounds, methods of preparing the compounds, and methods for use of the compounds in the treatment of PCSK9-related conditions and diseases.
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Paragraph 00232; 00239
(2020/12/30)
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- Light-Induced Gold-Catalyzed Hiyama Arylation: A Coupling Access to Biarylboronates
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Organoboron compounds are versatile synthetic building blocks. We herein report a new strategy, a photochemical gold-catalyzed chemo-selective Hiyama arylation of B,Si bifunctionalized reagents with diazonium salts, which is orthogonal to common strategies and therefore a unique tool for synthesis of valuable biarylboronates. With this new methodology a wide array of diversely functionalized sp2- and sp3-hybridized biarylboronates were obtained. Notably, the synergism of gold catalysis with copper catalysis or palladium catalysis, allows for one-pot iterative C?X (heteroatom) and C?C couplings for the rapid assembly of several simple fragments to relatively complex molecules. Mechanistic studies indicated that photosensitizer-free conditions were superior to gold/Ru(bpy)3Cl2 dual catalysis.
- Xie, Jin,Sekine, Kohei,Witzel, Sina,Kr?mer, Petra,Rudolph, Matthias,Rominger, Frank,Hashmi, A. Stephen K.
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p. 16648 - 16653
(2018/12/04)
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- Rhodium-Catalyzed Decarbonylative Borylation of Aromatic Thioesters for Facile Diversification of Aromatic Carboxylic Acids
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Transformation of aromatic thioesters into arylboronic esters was achieved efficiently using a rhodium catalyst. The broad functional-group tolerance and mild conditions of the method have allowed for the two-step decarboxylative borylation of a wide range of aromatic carboxylic acids, including commercially available drugs.
- Ochiai, Hidenori,Uetake, Yuta,Niwa, Takashi,Hosoya, Takamitsu
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p. 2482 - 2486
(2017/02/23)
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- ANTIVIRAL 2-CARBOXY-THIOPHENE COMPOUNDS
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Anti-viral agents of compounds of Formula (I) : wherein A, R1, R2 and R3 are as defined in the specification, processes for their preparation and their use in HCV treatment are provided.
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Page/Page column 34-35
(2008/06/13)
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