The present invention relates to compounds that inhibit LSD1 activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical com
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Paragraph 0212
(2017/05/20)
CYCLOPROPYLAMINES AS LSD1 INHIBITORS
The present invention is directed to cyclopropylamine derivatives which are LSD1 inhibitors useful in the treatment of diseases such as cancer.
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Paragraph 0414; 0415
(2015/09/22)
Synthesis of N1 -alkyl-1,4-diazepin-5-ones via Schmidt ring expansion chemistry
Reaction of 4-piperidone with alkyl bromides gave the corresponding N-alkyl-4-piperidones, and treatment of these with hydrazoic acid resulted in the Schmidt reaction to give the corresponding N1-alkyl-1,4-diazepin- 5-ones in good overall yield
Frick, Morin,McAtee, Danielle,McAtee, Jesse,Wysoczynski, Christina,Ray, Partha S.
experimental part
p. 17 - 19
(2011/10/02)
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