- A highly efficient route to C-3 alkyl-substituted indoles via a metal-free transfer hydrogenation
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A highly efficient route to C-3 alkyl-substituted indoles via completely metal-free catalytic transfer hydrogenation of 3-indolemethanols was developed. This process proceeds via vinylogous iminium intermediates formed in situ in the presence of Br?nsted
- Chen, Cai,Feng, Huan-Xi,Li, Zhi-Long,Cai, Pin-Wen,Liu, Yan-Kai,Shan, Lian-Hai,Zhou, Xian-Li
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supporting information
p. 3774 - 3776
(2014/07/07)
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- Enantioselective synthesis of triarylmethanes by chiral imidodiphosphoric acids catalyzed friedel-crafts reactions
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The first enantioselective synthesis of pyrrolyl-substituted triarylmethanes has been accomplished using a novel imidodiphosphoric acid catalyst, which is derived from two (R)-BINOL frameworks with different 3,3′-substituents. This strategy was also expanded to the synthesis of bis(indolyl)-substituted triarylmethanes with high enantioselectivities, which could only be obtained with moderate ee values in previous reports. These two efficient Friedel-Crafts alkylation processes feature low catalyst loading, broad functional group compatibilities, and the potential to provide practical pathways for the synthesis of enantioenriched bioactive triarylmethanes.
- Zhuo, Ming-Hua,Jiang, Yi-Jun,Fan, Yan-Sen,Gao, Yang,Liu, Song,Zhang, Suoqin
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supporting information
p. 1096 - 1099
(2014/03/21)
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- The direct asymmetric alkylation of α-amino aldehydes with 3-indolylmethanols by enamine catalysis
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This work describes an efficient α-alkylation reaction of α-amino aldehydes with 3-indolylmethanols. In the promotion of catalyst 3f, the target products were obtained in high yields (up to 99%), good diastereoselectivities (up to 88:12), and excellent en
- Guo, Zhi-Lei,Xue, Jia-Hui,Fu, Li-Na,Zhang, Shun-En,Guo, Qi-Xiang
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supporting information
p. 6472 - 6475
(2015/01/16)
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