Visible-Light-Promoted Synthesis of 1,4-Dicarbonyl Compounds via Conjugate Addition of Aroyl Chlorides
A facile visible-light photocatalytic conjugate addition to prepare 1,4-dicarbonyl compounds has been developed by employing readily available aroyl chlorides as aryl radical sources. This operationally simple method shows a broad scope with regard to both aroyl chlorides and Michael acceptors. As a result, a variety of 1,4-diketones were efficiently synthesized in moderate to good yields.
AMINONITRILE AND CYANOHYDRIN ETHERS AS BENZOYL ANION EQUIVALENTS IN CONJUGATE ADDITIONS TO SUBSTITUTED α CYCLENONES : COMPARATIVE SYNTHETIC POTENTIALITIES
Lithiated aminonitrile 1a and cyanohydrin ether 2a are good nucleophilic benzoyl equivalents in conjugate addition to α cyclenones. 1a is more sensitive to β substitution of the cyclenone than 2a, as in THF it does not react with 3-methyl substituted cycl
ADDITION CONJUGUEE D'AMINONITRILES, EQUIVALENTS DE BENZOYLE, AUX CYCLENONES. QUELQUES EXEMPLES DE SYNTHESES STEREOSELECTIVES DE CYCLANONES 2,3-DISUBSTITUEES CIS.
Conjugate addition of benzoyl anion equivalents to unsubstituted and 2-substituted cyclenones is proved in some cases to be highly stereoselective.Cis 2-methyl 3-benzoyl cyclanones are obtained with excellent yields.
Zervos, M.,Wartski, L.
p. 4641 - 4644
(2007/10/02)
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