- PROCESS FOR THE PREPARATION OF MONTELUKAST AND ITS SALTS THEREOF
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The present invention relates to the alkyl amine salts of Montelukast and methods for their preparation and conversion of Montelukast amine salts to Montelukast or Montelukast alkali/alkaline salt.
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- PROCESS FOR THE PREPARATION OF MONTELUKAST AND ITS SALTS THEREOF
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The present invention relates to the alkyl amine salts of Montelukast and methods for their preparation and conversion of Montelukast amine salts to Montelukast or Montelukast alkali/alkaline salt.
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Page/Page column 12
(2008/06/13)
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- Purification process of montelukast and its amine salts
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It comprises a process for the purification of Montelukast, or its salts or its solvates, including any stereoisomer or mixture thereof, which comprises converting Montelukast acid or a solvate thereof, including any stereoisomer or mixtures thereof, into an amine salt selected from the group consisting of cyclohexylamine, tris-(hydroxymethyl)aminomethane, L-(+)-treo-2-amino-1-phenyl-1,3-propanediol, R-(+)-α-methylbenzylamine, and L-(+)-α-phenylglycinol salt, in the presence of an appropriate solvent. It also comprises novel salts of Montelukast, in particular, cyclohexylamine, tris-(hydroxymethyl)aminomethane, L-(+)-treo-2-amino-1-phenyl-1,3-propanediol, R-(+)-α-methylbenzylamine, and L-(+)-α-phenylglycinol salts.
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Page/Page column 8-9
(2008/06/13)
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- PROCESS FOR PREPARING MONTELUKAST SODIUM CONTAINING CONTROLLED LEVELS OF IMPURITIES
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The present invention is directed to a process of preparing montelukast or a salt thereof with minimal amounts of impurities, such as a dehydration impurity (compound (VI)) or a cyclic ether impurity (compound (VIII)).
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Page/Page column 19
(2008/12/07)
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- PROCESS FOR THE PREPARATION OF MONTELUKAST, AND INTERMEDIATES THEREFOR
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The invention relates to processes for making montelukast and to intermediates for use in the process, in particular compounds of formulas 2-7: L=OAc, OTs, OTf5OMs; where X=Cl, Br, I.
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Page/Page column 26-27
(2008/06/13)
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- PROCESS FOR PREPARING MONTELUKAST SODIUM CONTAINING CONTROLLED LEVELS OF IMPURITIES
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The present invention is directed to a process of preparing montelukast or a salt thereof with minimal amounts of impurities, such as a dehydration impurity (compound (VI)) or a cyclic ether impurity (compound (VIII)).
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Page/Page column 9
(2008/12/07)
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- Novel Compounds and Preparation for Montelukast Sodium
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This invention relates to novel compounds and a process for preparation of montelukast sodium.
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Page/Page column 4
(2008/06/13)
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- PROCESS FOR THE PREPARATION OF MONTELUKAST FREE ACID AND ITS AMINE SALTS
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The present invention provides a process for the preparation of montelukast and its pharmaceutically acceptable salts which comprises, preparation of montelukast novel amine salt and conversion to montelukast free acid, further conversion of the obtained montelukast free acid to the corresponding pharmaceutically acceptable salts of montelukast. The present invention also provides novel amine salts of montelukast.
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Page/Page column 8
(2010/11/30)
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- NOVEL PROCESS FOR PREPARING 1-(MERCAPTOMETHYL) CYCLOPROPANEACETIC ACID, A USEFUL INTERMEDIATE IN THE PREPARATION OF MONTELUKAST AND SALTS THEREOF
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The present invention provides a novel montelukast intermediate and a simple and straightforward process for preparing it. According to the present invention, by using this intermediate and the process, essentially as described herein, montelukast acid and salts thereof are obtained.
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Page/Page column 9; 14
(2008/06/13)
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- NOVEL POLYMORPHS OF MONTELUKAST AMMONIUM SALTS AND PROCESSES FOR PREPARATION THEREFOR
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Novel crystalline forms I, II, III, IV, V, VI, VII, VIII, IX, and X of montelukast ammonium salts are provided, and novel methods of making these forms are disclosed
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Page/Page column 28
(2008/06/13)
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- Process for preparing montelukast and salts thereof
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The present invention provides a process for preparing highly pure montelukast and salts thereof by reacting the side-chain precursor 1-(mercaptomethyl)-cyclopropaneacetic acid with 2-(2-(3S)-(3-(7-chloro-2-quinolinyl)-ethenyl)phenyl)-3-(methanesulfonyloxypropyl)phenyl-2-propanol in a solvent mixture containing a base.
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Page/Page column 5
(2008/06/13)
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