- Method for preparing sodium 3-nitrobenzene sulfonate and derivative thereof through chlorosulfonic acid sulfonation
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The invention discloses a method for preparing sodium 3-nitrobenzene sulfonate and a derivative thereof through chlorosulfonic acid sulfonation. The method comprises the following steps: 1) putting anitrobenzene raw material and chlorosulfonic acid into a reaction container, heating to 90-150 DEG C, keeping the temperature, carrying out a sulfonation reaction, and discharging a hydrogen chloridegas generated in the reaction process outside the reaction system in time, wherein the mole ratio of the nitrobenzene raw material to the chlorosulfonic acid is 1:(0.4-0.6); 2) carrying out aftertreatment on the reaction liquid obtained in the step 1) by using soda, thereby obtaining the sodium 3-nitrobenzene sulfonate or the derivative thereof. By adopting the method, a reverse thinking mode is adopted, the amount of the chlorosulfonic acid is reduced till being smaller than that of the nitrobenzene, and then the small amount of the chlorosulfonic acid can be converted by using the excessiveamount of the nitrobenzene; therefore, the method disclosed by the invention has no problem of treating residual chlorosulfonic acid; in addition, the excessive nitrobenzene can be easily recycled andcirculated, the hydrogen chloride as a byproduct can be also easily separated and recycled.
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Paragraph 0092; 0093; 0094; 0095; 0096
(2019/01/07)
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- Novel dye intermediate and active dye prepared from dye intermediate
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The invention relates to a novel dye intermediate and active dye prepared from the dye intermediate. The dye intermediate has the structural formula shown as a formula in the accompanying drawing. The dye intermediate has the advantages that on the basis of para-cresidine ester, the condensation is performed with p-nitrochlorobenzene-o-sulfonic acid; then, further reaction is performed to prepare the novel KN-property active dye intermediate. The color of the prepared dye is more vivid; the solubility is better.
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Paragraph 0033; 0034; 0035; 0036; 0037; 0038; 0039; 0040
(2017/05/27)
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- Research on controllable degradation of sulfonylurea herbicides
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In order to seek ecologically safer and environmentally benign sulfonylurea herbicides (SU), insight into the structure/bioassay/soil degradation tri-factor relationship was first established. With the introduction of various groups (alkyl, nitro, halogen, cyano etc.) at the 5th position of its benzene ring, structural derivatives of chlorsulfuron were designed, synthesized, and evaluated for their herbicidal activity. The structures of the title compounds were confirmed by infrared spectroscopy, ultraviolet spectroscopy, 1H and 13C NMR, mass spectrometry, elemental analysis and X-ray diffraction. Bioassay results confirmed that most derivatives retained their superior herbicidal activities in comparison with chlorsulfuron. After investigating the soil degradation behavior of each molecule under set conditions, it was found that structures with electron-withdrawing substituents at the 5th position of the benzene ring retained their long degradation half-lives, yet the introduction of electron-donating substituents accelerated the degradation rate. These results will provide a valuable clue to further explore the potential controllable degradation of SU and other herbicides, and to discover novel herbicides that are favorable for environmentally and ecologically sustainable development.
- Hua, Xue-Wen,Chen, Ming-Gui,Zhou, Shaa,Zhang, Dong-Kai,Liu, Ming,Zhou, Sha,Liu, Jing-Bo,Lei, Kang,Song, Hai-Bin,Li, Yong-Hong,Gu, Yu-Cheng,Li, Zheng-Ming
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p. 23038 - 23047
(2016/03/12)
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- Synthesis and evaluation of novel monosubstituted sulfonylurea derivatives as antituberculosis agents
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A series of novel monosubstituted sulfonylurea derivatives 10a-y were synthesized and characterized by 1H NMR, 13C NMR and HRMS. These compounds were evaluated against Mycobacterium tuberculosis H37Rv in vitro. The results showed compounds 10f, 10k and 10s exhibited moderate antituberculosis activities with MIC values in the range of 20-100 mg/L. Compounds 10b and 10o displayed good antituberculosis activities (MIC 10 mg/L), which were comparable with that of the sulfometuron methyl. Both of the two compounds showed little cytotoxicities, with an IC50 against THP-1 cells greater than 100 mg/L.
- Pan, Li,Jiang, Ying,Liu, Zhen,Liu, Xing-Hai,Liu, Zhuo,Wang, Gang,Li, Zheng-Ming,Wang, Di
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- NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION
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The embodiments provide compounds of the general Formulae I, II, III, IV, or V as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
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Page/Page column 292-293
(2011/07/06)
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- General and Highly Efficient Syntheses of m-Fluoro Arenes Using Potassium Fluoride-Exchange Method
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Tetraphenylphosphonium bromide was found to be a suitable catalyst for the reaction of m-nitroaryl derivatives carrying cyano, nitro, chlorocarbonyl, trifluoromethyl, and chlorosulfonyl groups with potassium fluoride in the presence of a stoichiometric amount of phthaloyl dichloride, giving the corresponding m-fluoro aromatic derivatives in good yields.The catalyst was also found to be efficient for the fluorodesulfonylation of m-(fluorosulfonyl)aryl derivatives to afford m-fluoro arenes by the use of a reaction-distillation technique.
- Suzuki, Hiroshi,Yazawa, Naoto,Yoshida, Yasuo,Furusawa, Osamu,Kimura, Yoshikazu
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p. 2010 - 2017
(2007/10/02)
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