A selenazole armor acid compounds and salts thereof
The invention relates to a selenazole acid compound as shown in the formula I or a pharmaceutically acceptable salt, aquo-complex and solvate, and provides a preparation method of the compound and an application of the compound in preparation of a medicin
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Paragraph 0053; 0055; 0057-0059
(2016/11/24)
Halodeboronation of organotrifluoroborates using tetrabutylammonium tribromide or cesium triiodide
Halodeboronation of organotrifluoroborates using commercially available tetrabutylammonium tribromide (TBATB) or cesium triiodide in aqueous medium is reported. The mild, transition metal-free method has proven to be tolerant of a wide range of functional groups. High regio- and chemoselectivity are observed. Two synthetic routes to (Z)-dibromoalkenes from alkynes, through stereodefined (Z)-2-bromoalkenyltrifluoroborates and (Z)-1,2-bis(boryl) alkenyltrifluoroborates, have been developed using the TBATB mediated bromodeboronation as the key step.
Yao, Min-Liang,Kabalka, George W.,Blevins, David W.,Reddy, Marepally Srinivasa,Yong, Li
experimental part
p. 3738 - 3743
(2012/06/30)
Chemoselective bromodeboronation of organotrifluoroborates using tetrabutylammonium tribromide: Application in (Z)-dibromoalkene syntheses
(Chemical Equation Presented) Tetrabutylammonlum trlbromlde (TBATB) has been found to be a unique bromodeboronatlon reagent for organotrlf luoroborates. When compared to previously reported bromodeboronatlon methods, the mild and metal-free reaction conditions tolerate a wider range of functional groups. High reglo- and chemoselectlvlty are observed In the presence of both unsaturated carbon-carbon bonds and aldehyde functional groups. An efficient synthetic route to (Z)-dlbromoalkenes from terminal alkynes has been developed using the TBATB-medlated bromodeboronatlon as a key step.
Yao, Min-Liang,Reddy, Marepally Srinivasa,Li, Yong,Walfish, Ingrid,Blevins, David W.,Kabalka, George W.
supporting information; experimental part
p. 700 - 703
(2010/04/02)
Synthesis of C-linked immobilized analogs of aloisine A by 'click' chemistry
An efficient approach for the immobilization of a series of analogs of aloisine A, an in vitro inhibitor of protein kinases, to polymeric supports via a [3+2] cycloaddition reaction is reported.
Haddoub, Rose,Gueyrard, David,Goekjian, Peter G.
body text
p. 741 - 744
(2009/04/19)
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