Synthesis of benzo[a]quinolizines by the intramolecular double michael reaction under three different conditions
Benzo[a]quinolizines (4A-C) and (5A-C) were synthesized by the intramolecular double Michael reaction of amide esters (3A-C), carried out using three reagent systems; TBDMSOTf-Et3N, TMSI-(TMS)2NH, and Bu2BOTf-(TMS)2/
STEREOCONTROLLED CONSTRUCTION OF OCTAHYDROQUINOLIZINES, OCTAHYDROINDOLIZINES, HEXAHYDROBENZOQUINOLIZINES, AND AN OCTAHYDROINDOLOQUINOLIZINE BY AN INTERMOLECULAR DOUBLE MICHAEL REACTION: SYNTHESIS OF (+/-)-EPILUPININE
Stereocontrolled one-step syntheses of octahydroquinolizine and octahydroindolizine derivatives from α,β-unsaturated enamide esters was achieved under two different conditions; heating in the presence of chlorotrimethylsilane, triethylamine, and zinc chlo
A NOVEL SYNTHESIS OF BENZO- AND INDOLOQUINOLIZIDINES BY INTRAMOLECULAR DIELS-ALDER REACTION OF 1-AZADIENES
Intramolecular Diels-Alder reaction of 1-azadienes was conducted by heating the α,β-unsaturated amides ( 2a - d and 6 ) in the presence of trimethylchlorosilane, triethylamine and zinc chloride to give benzo- and indoloquinolizidines ( 5a - d and 7 ).