The present invention provides a process for the synthesis of olopatadine. Further, the invention discloses a process that results in improved yield of the desired Z isomer.
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(2014/10/03)
PROCESS FOR PREPARATION OF OLOPAT ADINE HYDROCHLORIDE
Disclosed herein is a process for preparation of compound 11 - (Z) - [3 - (Dimethylamino) propylidene] - 6, 11 - dihydrodibenz [b, e] oxepin -2 - yl - acetic acid (Olopatadine) and its pharmaceutically acceptable salt; comprising reacting carboxylic acid protected 11 - oxo - 6, 11 - Dihydrodibenz [b, e] oxepin - 2 - acetic acid with 3 - dimethylaminopropyl triphenyl phosphonium halide in presence of a suitable base and an organic solvent.
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Page/Page column 11-12
(2009/07/25)
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