- Cycloaddition Reaction of in Situ Formed Azaoxyallyl Cations with Aldehydes: An Approach to Oxazolidin-4-ones
-
A novel [3 + 2] cycloaddition reaction between in situ formed azaoxyallyl cations and aldehydes has been developed. This concise method allows the rapid formation of a number of oxazolidin-4-ones in high yields with good functional group tolerance at room temperature. Further transformation and late-stage modifications of drug molecules could also be achieved in good yields, highlighting the potential utility of the reaction.
- Zhang, Kaifan,Yang, Chi,Yao, Hequan,Lin, Aijun
-
supporting information
p. 4618 - 4621
(2016/09/28)
-
- Synthesis, antiviral, cytotoxicity and antitumor evaluations of A4 type of porphyrin derivatives
-
This manuscript describes the synthesis of a new series of porphyrin structures 4a-4m, 7, 9, 12 and 14. These structures were investigated against two types of viruses such as HIV-1 and HSV-1. Also they were screened for their antitumor activity. Among all tested compounds, it was found that compound 4b showed a high activity against HIV-1 and HSV-1 and against four different tumor cell lines. Most of the tested compounds showed a moderate degree of a potent antimicrobial activity. The structure of these compounds was confirmed on the basis of their analytical and spectral data such as UV-vis, IR, 13C NMR, 1H NMR spectroscopy and mass spectral data.
- Fadda, Ahmed A.,El-Mekawy, Rasha E.,El-Shafei, Ahmed I.
-
p. 753 - 768
(2015/10/29)
-
- Synthesis, antiviral, cytotoxicity and antitumor evaluations of A4 type of porphyrin derivatives
-
This manuscript describes the synthesis of a new series of porphyrin structures 4a-4m, 7, 9, 12 and 14. These structures were investigated against two types of viruses such as HIV-1 and HSV-1. Also they were screened for their antitumor activity. Among all tested compounds, it was found that compound 4b showed a high activity against HIV-1 and HSV-1 and against four different tumor cell lines. Most of the tested compounds showed a moderate degree of a potent antimicrobial activity. The structure of these compounds was confirmed on the basis of their analytical and spectral data such as UV-vis, IR, 13C NMR, 1H NMR spectroscopy and mass spectral data.
- Fadda, Ahmed A.,El-Mekawy, Rasha E.,El-Shafei, Ahmed I.
-
p. 753 - 768
(2016/01/09)
-
- Synthesis of Some Antipyryl Methines. I. Asymmetrical Antipyryl Methines
-
A new series of asymmetrical antipyryl dimethine cyanines 2-7 was synthesized, starting with antipyrine aldehyde 1 and methylcarbenium salts, and the color change of the dyes was investigated as a function of the carbene moiety.
- Kokkinos, Konst.,Markopoulos, Chr.
-
p. 543 - 553
(2007/10/02)
-