- Benzimidazoles as potent and orally active mGlu5 receptor antagonists with an improved pk profile
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A focused chemical optimization effort of compound 1 based on metabolite elucidation is described, resulting in 15i, a highly potent and selective mGlu5 receptor antagonist with an improved pharmacokinetic profile compared to 1. Characterization of 15i in
- Carcache, David,Vranesic, Ivo,Blanz, Joachim,Desrayaud, Sandrine,Fendt, Markus,Glatthar, Ralf
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- NOVEL BI-ARYL AMINES
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The present invention relates to novel bi-aryl amines of formula (I) and to pharmaceutically acceptable prodrugs, salts, solvates, hydrates, and N-oxides thereof and to pharmaceutical compositions comprising them, methods of their use, and methods of their preparation.
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Page/Page column 33
(2008/06/13)
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