- One-Pot Synthesis of Dissymmetrical 4,6-Disubstituted Dibenzofurans
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The one-pot dissymmetrization of dibenzofuran has been achieved using directed ortho metallations.Effects of temperature, reaction time, stoichiometry of the lithiation reagent, and solvent were studied to obtain the best selectivity.
- Jean, Fabienne,Melnyk, Oleg,Tartar, Andre
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- Synthesis of Aldehydes by Organocatalytic Formylation Reactions of Boronic Acids with Glyoxylic Acid
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Reported herein is a conceptually novel organocatalytic strategy for the formylation of boronic acids. New reactivity is engineered into the α-amino-acid-forming Petasis reaction occurring between aryl boronic acids, amines, and glyoxylic acids to prepare aldehydes. The operational simplicity of the process and its ability to generate structurally diverse and valued aryl, heteroaryl, and α,β-unsaturated aldehydes containing a wide array of functional groups, demonstrates the practical utility of the new synthetic strategy.
- Huang, He,Yu, Chenguang,Li, Xiangmin,Zhang, Yongqiang,Zhang, Yueteng,Chen, Xiaobei,Mariano, Patrick S.,Xie, Hexin,Wang, Wei
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supporting information
p. 8201 - 8205
(2017/06/30)
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- Method for producing an aromatic heterocyclic compound, organic semiconductor material and organic semiconductor device
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PROBLEM TO BE SOLVED: To provide: an aromatic heterocyclic compound which has oxidation stability, high solubility, favorable film production properties and high charge transfer properties, and is suitable as an organic semiconductor material; and organic
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Paragraph 0094; 0095
(2017/06/20)
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- AROMATIC HETEROCYCLIC COMPOUND, MANUFACTURING METHOD THEREOF, ORGANIC SEMICONDUCTOR MATERIAL, AND ORGANIC SEMICONDUCTOR DEVICE
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Provided are an organic semiconductor material having a high charge mobility, oxidation stability, and solvent solubility, an organic semiconductor device using the same, and a novel aromatic heterocyclic compound to be used for the same and a production
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Paragraph 0199; 0200; 0201; 0202
(2016/11/28)
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- An expedient osmium(vi)/K3Fe(CN)6-mediated selective oxidation of benzylic, allylic and propargylic alcohols
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A chemoselective osmium(vi) catalyzed oxidation of benzylic, allylic and propargylic alcohols using K3Fe(CN)6as a secondary oxidant is described. This protocol is operationally simple and exhibits excellent chemoselectivity favouring the oxidation of benzylic alcohols over the aliphatic alcohols. A larger scale reaction was also found to be compatible. This journal is
- Fernandes, Rodney A.,Bethi, Venkati
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p. 40561 - 40568
(2015/02/18)
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- AROMATIC AMINE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT ELEMENT COMPRISING SAME
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An aromatic amine derivative represented by the following formula (1): wherein A1 is a substituted or unsubstituted alkyl group, a substituted or unsubstituted aromatic group, a substituted or unsubstituted heterocyclic group or an organic group represented by the following formula (2): wherein X1, X2 and X3 are independently a substituted or unsubstituted aromatic group or a substituted or unsubstituted heterocyclic group; X1 and X2 are linkage groups which are different from each other; and B1, B2 and B3 are independently a substituted or unsubstituted aromatic group or a substituted or unsubstituted heterocyclic group.
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Page/Page column 56
(2012/03/26)
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- Synthesis and evaluation of some novel dibenzo[b,d]furan carboxylic acids as potential anti-diabetic agents
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A series of novel dibenzo[b,d]furan mono-carboxylic acid derivatives were synthesized, characterized and evaluated for their ability to inhibit Protein Tyrosine Phosphatase 1B (PTP1B) in vitro in order to use them as potential anti-diabetic agents. Structure-activity relationship study led to the identification of potent compound 5E which inhibited PTP1B with IC50 value of 82 ± 0.43 nM. Compound 5E was screened in vivo as drug candidate for anti-diabetic activity using rosiglitazone maleate as the standard. Compound 5E showed significant reduction in body weight, fed-state whole blood glucose (WBG), fasting WBG, plasma glucose and plasma cholesterol levels and non-significant reduction in fasting plasma triglyceride levels in ob/ob mice. A series of dibenzo[b,d]furan carboxylic acids were synthesized and evaluated for anti-diabetic activity. Compound 5E inhibited PTP1B with IC50 of 82 nM and reduced WBG and plasma glucose in ob/ob mice.
- Lakshminarayana,Prasad, Y. Rajendra,Gharat, Laxmikant,Thomas, Abraham,Narayanan, Shridhar,Raghuram,Srinivasan,Gopalan, Balasubramanian
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experimental part
p. 3709 - 3718
(2010/11/04)
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- Selective product amplification of thymine photodimer by recognition-directed supramolecular assistance
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Two symmetric ditopic supramolecular templates (1 and 2) each presenting two hydrogen bonding recognition subunits were synthesized. Each such subunit comprises the same donor and acceptor pattern, capable of binding a substrate molecule with complementar
- Skene,Berl, Volker,Risler, Helene,Khoury, Richard,Lehn, Jean-Marie
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p. 3652 - 3663
(2008/10/09)
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- Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives
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The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions of compounds of Formula (A): wherein Ar, Y, R1 and q are as defined herein; and their use in the treatment of diseases, including treatment of sleepiness, promotion of wakefulness, treatment of Parkinson's disease, cerebral ischemia, stroke, sleep apneas, eating disorders, stimulation of appetite and weight gain, treatment of attention deficit hyperactivity disorder ("ADHD"), enhancing function in disorders associated with hypofunctionality of the cerebral cortex, including, but not limited to, depression, schizophrenia, fatigue, in particular, fatigue associated with neurologic disease, such as multiple sclerosis, chronic fatigue syndrome, and improvement of cognitive dysfunction.
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Page/Page column 28
(2008/06/13)
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- Conformationally restricted diamines as spacers for parallel β-sheet formation
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The dibenzofuran-based diamide 4,6-bis(N-acyl-aminomethyl)dibenzofuran is shown by 1H NMR and IR to have favourable geometry for intramolecular hydrogen bonding. The corresponding dibenzothiophene-based diamide 4,6-bis(N-acyl-aminomethyl)dibenzothiophene does not fulfill the geometric requirements for intramolecular hydrogen bonding. The intramolecularly hydrogen bonded state of the dibenzofuran-based diamide la is found to be 1 ± 0.5 kcal/mol more favoured enthalpically and 4 ± 2 cal/(K·mol) disfavoured entropically than the non-hydrogen bonded state.
- Skar, Merete L.,Svendsen, John S.
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p. 17425 - 17440
(2007/10/03)
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- 4-Heterotricyclic substituted 1,4-dihydropyridines with a potent selective bradycardic effect
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A series of 4-heterotricyclic substituted 1,4-dihydropyridines were prepared. The compounds were evaluated for inotropic, chronotropic and calcium antagonist properties. The tested compounds are fairly good as calcium antagonists, but exert potent selective bradycardic effects.
- Rampa,Chiarini,Bisi,Budriesi,Valenti
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p. 705 - 709
(2007/10/02)
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