- PREPARATION OF 2--2,3-DIHYDROOXAZOLOISOINDOL-5(9bH)-ONE DERIVATIVES AND A NEW SYNTHESIS OF THIAMPHENICOL ANALOGUES
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A new procedure of protection-deprotection of the amino group and, regioselectively, of the secondary hydroxyl in 2-amino-1--1,3-propanediol, 5, has been developed; this procedure facilitates the synthesis of thiamphenicol analogues with potential antibiotic activity.A new synthesis of the 3-fluoro analogue, 3, and the synthesis of intermediates potentially useful in the preparation of the 3-chloro, 3-bromo, 3-iodo, and 3-acetylthio analogues are described.
- Jommi, Giancarlo,Pagliarin, Roberto,Chiarino, Dario,Fantucci, Mario
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p. 653 - 658
(2007/10/02)
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