cas 96946-42-8, Cisatracurium besylate | Articles data ｜lookchem

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96946-42-8

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Method for synthesizing cisatracurium besilate
The invention discloses a method for synthesizing cisatracurium besilate. The method comprises the following steps of: reacting a compound shown as formula I, a compound shown as formula II and oxalicacid dihydrate to generate a compound shown as formula III; reacting the compound shown as formula III under the catalysis of Pd/C to generate a compound shown as formula IV; reacting the compound shown as formula IV with 1, 5-pentanediol to generate a compound shown as formula V; and reacting the compound shown as formula V with methyl benzenesulfonate to prepare cisatracurium besilate; whereinthe compounds shown as the formula I, the formula II, the formula III, the formula IV and the formula V are respectively represented as the specification. The synthesis method provided by the invention can significantly improve the yield and purity of cisatracurium besilate and reduce the synthesis cost of cisatracurium besilate.
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(2021/03/06)

NOVEL PROCESS FOR THE PREPARATION OF CISATRACURIUM BESYLATE
The present invention is related to a novel process for the preparation of cisatracurium besylate, more particularly optically and geometrically pure cisatracurium besylate in large scale.
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Page/Page column 8; 12

(2010/11/18)

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Chemical Properties

Appearance/Colour :white solid
Melting Point: 90-93 °C
Solubility:H2O: soluble1mg/mL
Storage Temp.:Amber Vial, -20°C Freezer, Under Inert Atmosphere
PSA: 257.60000
LogP: 11.32610

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