Synthesis method of 5-fluoro-2-(1-bromocyclopropyl) pyridine
The invention relates to a synthesis method of 5-fluoro-2-(1-bromocyclopropyl) pyridine. 1,4-butyrolactone, ethyl 4-bromobutyrate and 5-fluoro-2-mercaptopyridine are used as raw materials to prepare 5-fluoro-2-(1-bromocyclopropyl) pyridine through eleven steps of reaction. A synthetic route of the 5-fluoro-2-(1-bromocyclopropyl) pyridine is as follows: (as described in the specification). The invention has the advantages that the synthesis method of 5-fluoro-2-(1-bromocyclopropyl) pyridine improves the yield and provides an efficient synthesis method for the synthesis of the compound.
Synthesis method of 1-(1-halogenated cyclopropyl) formic ether compound
The invention discloses a synthesis method of a 1-(1-halogenated cyclopropyl) formic ether compound. The 1-(1-halogenated cyclopropyl) formic ether compound is prepared by taking a 2,4-dihalogenated butyrate compound as a raw material and under the action of dihydric alcohol sodium. The method disclosed by the invention is rapid in reaction and high in yield, and solves the problem that the 1-(1-halogenated cyclopropyl) formic ether compound can not be simply and rapidly synthesized. The synthesis method is used for preparing the 1-(1-halogenated cyclopropyl) formic ether compound.
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Paragraph 0024-0025
(2017/06/08)
An efficient synthesis of 1-bromo-1-cyanocyclopropane
An efficient process for the synthesis of 1-bromo-1-cyanocyclopropane has been developed starting from inexpensive γ-butyrolactone via bromination, cyclisation, ammoniation and dehydration reaction. The sequence proceeds in good yield.
Xue, Feng,Li, Chang-Gong,Zhu, Yong,Lou, Tian-Jun
p. 418 - 419
(2014/08/05)
Trispirododecane-4,8,12-trione and Other Oligomers of Carbonylcyclopropane. The Organozinc Route
1-Bromocyclopropanecarboxylic acid (8) and its chloride (9) were prepared from γ-butyrolactone on a 20-100-g scale.Dehalogenation of 9 with zinc-copper couple in acetonitrile gave not only the known dispiro octane-4,8-dione (3) but also the aesthetically pleasing title compound 10 and 6-cyclopropylidene-5-oxaspirohexan-4-one (11) as well as tetracyclic α-alkylidene-γ-butyrolactone 12, i.e., 3-(oxodispirooctan-4-ylidene)tetrahydro-2-furanone. "Zinc carbon enolate" 13a is considered to be an important intermediate en route to 10 in solventacetonitrile.The X-ray crystal structure of 10 shows the molecule to be nearly planar with very short distal cyclopropane carbon-carbon bonds .
Hoffmann, H. Martin R.,Eggert, Ulrike,Walenta, Angela,Weineck, Edeltraut,Schomburg, Dietmar,et al.
p. 6096 - 6100
(2007/10/02)
Trispirododecan-4,8,12-trion
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Hoffmann, H. M. R.,Walenta, Angela,Eggert, Ulrike,Schomburg, Dietmar
p. 599 - 600
(2007/10/02)
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