- Copper-Catalyzed Redox-Triggered Remote C-H Functionalization: Highly Selective Formation of C-CF3 and C-O Bonds
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A Cu-catalyzed remote sp3 C-H/unactivated alkenes functionalization reaction for the concomitant construction of C-CF3 and C-O bonds was described. An 1,5-H radical transfer involving an sp3 C-H bond adjacent to a nitrogen atom and an α-CF3-alkyl radical intermediate derived from unactivated alkenes was observed and demonstrated to proceed via the radical process. C-CF3 formation/1,5-H radical shift/remote functionalization of sp3 C-H bond.
- Li, Taotao,Yu, Peng,Lin, Jin-Shun,Zhi, Yonggang,Liu, Xin-Yuan
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supporting information
p. 490 - 494
(2016/06/01)
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- Palladium(II)-catalyzed intramolecular tandem aminoalkylation via divergent C(sp3)-H functionalization
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(Chemical Equation Presented) We have developed a Pd(II)-catalyzed oxidative tandem aminoalkylation via divergent C(sp3)-H functionalization, a ffording three- and five-membered-ring fused indolines in good yields under two optimized conditions, respectively. The mechanism studies have indicated that the benzylic C - H cleavage involved in the former transformation is the rate-determining step, while the cleavage of amide α-C - H in the latter is not. This is the first example of a Pd-catalyzed tandem reaction involving C(sp3)-H activation without the employment of prefunctionalized reagents (e.g., halogenated and boron reagents) and directing groups, representing a green and economic protocol for the construction of N-containing heterocycles.
- Du, Wei,Gu, Qiangshuai,Li, Zhongliang,Yang, Dan
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supporting information
p. 1130 - 1135
(2015/02/05)
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- Phosphine-catalyzed remote β-C-H functionalization of amines triggered by trifluoromethylation of alkenes: One-pot synthesis of bistrifluoromethylated enamides and oxazoles
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An unprecedented phosphine-catalyzed remote β-C-H functionalization of amine derivatives triggered by trifluoromethylation of an alkene with Togni's reagent was disclosed. This reaction proceeded through the highly selective and concomitant activation of
- Yu, Peng,Zheng, Sheng-Cai,Yang, Ning-Yuan,Tan, Bin,Liu, Xin-Yuan
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supporting information
p. 4041 - 4045
(2015/03/30)
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- Photosubstitution of Dicyanobenzenes by Allylic Silanes, Germanes, and Stannanes via Photoinduced Electron Transfer
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Photoreactions of 1,2- and 1,4-dicyanobenzenes (o- and p-DCB) with allylic silanes, germanes, and stannanes in acetonitrile were studied under various conditions.In these photoreactions, one of cyano groups of o- and p-DCB was replaced by allylic groups.W
- Nakanishi, Kazuhisa,Mizuno, Kazuhiko,Otsuji, Yoshio
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p. 2371 - 2379
(2007/10/02)
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- A NOVEL PHOTOSUBSTITUTION OF DICYANOBENZENES BY ALLYLIC AND BENZYLIC SILANES
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The photosubstitution of o- and p-dicyanobenzenes by allylic and benzylic silanes in acetonitrile occurred efficiently, giving the corresponding mono-allylated and benzylated cyanobenzenes.
- Mizuno, Kazuhiko,Ikeda, Munehiro,Otsuji, Yoshio
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p. 461 - 464
(2007/10/02)
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