INHIBITORS OF VIRAL REPLICATION, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES
Inhibitors of viral replication of formula (I), their process of preparation and their therapeutical uses. The present invention relates to compounds, their use in the treatment or the prevention of viral disorders, including HIV.
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Page/Page column 143
(2014/05/07)
Modification of the pyridine moiety of non-peptidyl indole GnRH receptor antagonists.
The synthesis of a number of indole GnRH antagonists is described. Oxidation of the pyridine ring nitrogen, combined with alkylation at the two position, led to a compound with an excellent in vitro activity profile as well as oral bioavailability in both rats and dogs.
Simeone, Joseph P,Bugianesi, Robert L,Ponpipom, Mitree M,Yang, Yi Tien,Lo, Jane-Ling,Yudkovitz, Joel B,Cui, Jisong,Mount, George R,Ren, Rena Ning,Creighton, Mellissa,Mao, An-Hua,Vincent, Stella H,Cheng, Kang,Goulet, Mark T
p. 3329 - 3332
(2007/10/03)
Regiospecific α-Alkylation of 4-Chloro(bromo)pyridine
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Comins, Daniel L.,Mantlo, Nathan B.
p. 4410 - 4411
(2007/10/02)
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