Transbromination of brominated pyrrole and imidazole derivatives: Synthesis of the C11N5 marine alkaloid stevensine
The marine sponge alkaloid stevensine (3) has been synthesized from the related C11N5 alkaloid, hymenin (1). The key transformation involves a regioselective protodebromination/transbromination event of 4'-bromohymenin (2) to install the olefin in 3. Such processes are seldom used for synthetic purposes but appear to be highly applicable to the C11N5 family of marine alkaloids.
Xu, Ying-Zi,Yakushijin, Kenichi,Horne, David A.
p. 8121 - 8124
(2007/10/03)
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