- Facile synthesis of pyrazolo[3,4-d]pyrimidines and pyrimido[4,5-d] pyrimidin-4-one derivatives
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Pyrazolopyrimidine and pyrimidopyrimidine derivatives have shown a wide range of biological activities such as acting as A1 adenosine receptors, kinase insert domain receptor (KDR), Rous sarcoma oncogene (Src), epidermal growth factor receptor (EGFR), antiproliferative, dihydrofolate reductase (DHFR), antimicrobial, antifungal, and lipid peroxidation. Because of this wide range of activities, we have synthesized pyrazolo[3,4-d]pyrimidines and pyrimido[4,5-d]pyrimidin-4-one derivatives. Copyright Taylor & Francis Group, LLC.
- Katiyar, Sanjay Babu,Kumar, Arun,Chauhan, Prem M. S.
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p. 2963 - 2973
(2007/10/03)
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- A Convenient Synthesis of 2-Substituted 4-Amino-5-pyrimidinecarbonitriles
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Synthesis of the novel 2-halogenated 4-amino-5-pyrimidinecarbonitriles 3a,b starting from ethoxymethylenemalononitrile 1 and cyanamide is described.Nucleophilic substitution of the reactive halogen atom leads to the derivatives 5a-g,6 and 7a-h.
- Schmidt, Hans-Werner,Koitz, Gerald,Junek, Hans
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p. 1305 - 1307
(2007/10/02)
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