21691-41-8 Usage
General Description
Z-MEALA-OH, also known as Benzyloxycarbonyl-Met-Ala-Leu-Ala-OH, is a chemical compound primarily used in scientific research. It is particularly utilized in the field of biochemistry and molecular biology for peptide synthesis, which is essentially the production of peptides used in drug development and biochemical research. Peptides are chains of amino acids that are combined together in a specific order. Z-MEALA-OH is an important component in this process as its composition directly contributes to peptide synthesis. The "Z" in Z-MEALA-OH refers to a protective group used in peptide synthesis, and "OH" refers to a hydroxyl group, an important functional group in organic chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 21691-41-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,6,9 and 1 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 21691-41:
(7*2)+(6*1)+(5*6)+(4*9)+(3*1)+(2*4)+(1*1)=98
98 % 10 = 8
So 21691-41-8 is a valid CAS Registry Number.
InChI:InChI=1/C12H15NO4/c1-9(11(14)15)13(2)12(16)17-8-10-6-4-3-5-7-10/h3-7,9H,8H2,1-2H3,(H,14,15)
21691-41-8Relevant articles and documents
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Coggins,J.R.,Benoiton,N.L.
, p. 1968 - 1971 (1971)
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Synthesis of N-alkyl-N-methyl amino acids. Scope and limitations of base-induced N-alkylation of Cbz-amino acids
Stodulski, Maciej,Mlynarski, Jacek
, p. 970 - 975 (2008/09/21)
The reaction of N-benzyloxycarbonyl derivatives of aliphatic amino acids with NaH/alkyl iodides gave the corresponding N-Cbz-N-alkyl derivatives in good to high yields. The scope and limitations of this simple N-alkylation reaction were investigated as a convenient and flexible attempt to prepare unsymmetrically N,N-diprotected α-amino acids. The procedure is based on the N-alkylation of N-carbamoyl amino acids, a one-pot deprotection/protection sequence without extensive purification of the products. Protection of the carboxyl function is not required while the starting materials are inexpensive and commercially available.
A simple and rapid protocol for N-methyl-α-amino acids
Reddy, G. Vidyasagar,Iyengar
, p. 299 - 300 (2007/10/03)
A two step strategy for optically pure N-Protected-N-methyl-α-amino acids starting from N-protected-α-amino acids via reductive cleavage of oxazolidinones using NaCNBH3/TMSCl is described.