5241-58-7

Basic information

• Product Name: H-PHE-NH2
• Synonyms: H-PHE-NH2;H-L-PHE-NH2;L-PHENYLALANINE AMIDE;L-PHENYLALANINAMIDE;PHENYLALANINE-NH2;L-phenylalaninamide free base;H-Phe-Nh;2-Amino-3-phenylpropanamide
• CAS NO: 5241-58-7
• Molecular Formula: C₉H₁₂N₂O
• Molecular Weight: 164.2
• Product Categories: Phenylalanine [Phe, F];Amino Acids and Derivatives;Amino Acid Derivatives;Peptide Synthesis;Phenylalanine;Amino Acids;I - Z;Modified Amino Acids;Amino Acids & Derivatives;Aromatics;Chiral Reagents
• Mol File: 5241-58-7.mol
• Article Data: 60

Chemical Properties

• Melting Point: 93-95°C
• Boiling Point: 356.9 °C at 760 mmHg
• Flash Point: 169.7 °C
• Appearance: White/Powder
• Density: 1.143 g/cm³
• Storage Temp.: −20°C
• PKA: 15.85±0.50(Predicted)
• BRN: 6270941
• CAS DataBase Reference: H-PHE-NH2(CAS DataBase Reference)
• NIST Chemistry Reference: H-PHE-NH2(5241-58-7)
• EPA Substance Registry System: H-PHE-NH2(5241-58-7)

Safety Data

• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 5241-58-7(Hazardous Substances Data)

Usage

Description

H-PHE-NH2, also known as L-phenylalanine amide, is an amino acid amide derived from L-phenylalanine. It is an off-white solid and is characterized by its unique chemical properties.

Uses

Used in Pharmaceutical Industry:
H-PHE-NH2 is used as an active pharmaceutical ingredient for its potential therapeutic applications. It plays a crucial role in the synthesis of various drugs and is involved in the treatment of several medical conditions.
Used in Food Industry:
H-PHE-NH2 is used as a flavor enhancer and additive in the food industry. Its unique taste and properties contribute to the enhancement of flavors in various food products.
Used in Cosmetic Industry:
H-PHE-NH2 is used as a key ingredient in the cosmetic industry, where it is utilized for its potential benefits in skincare and hair care products.
Used in Research and Development:
H-PHE-NH2 is used as a research compound in the field of biochemistry and molecular biology. It is essential for understanding the structure and function of proteins and other biological molecules.

InChI:InChI=1/C9H12N2O/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H2,11,12)/t8-/m0/s1

Upstream product

• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 
• 3081-24-1 H-Phe-OEt 
• 5241-56-5 benzyl [(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]carbamate 
• 73148-50-2 Z(OMe)-Phe-NH₂ 
• 24730-33-4 (S)-2-amino-3-phenylpropanamide hydrobromide 
• 155385-83-4 (-)-1-<(1-cyano-2-phenylethyl)amino>-2R-methyl-5R-(1-methylethenyl)cyclohexane-1R,3R-dicarbonitrile 
• 35661-40-6 N-Fmoc L-Phe 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 47091-50-9 Asp-Phe-NH₂ 
• 15028-44-1 DL-phenylalanine methyl ester 
• 88463-18-7 (S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropionamide 
• 17193-31-6 (R,S)-2-amino-3-phenylpropionamide 
• 33662-25-8 (S)-N-Boc-phenylalanine benzylamide 
• 2578-84-9 N-benzyloxycarbonyl-L-phenylalanine p-nitrophenyl ester 

Downstream Products

• 33900-05-9 tert-butyl (S)-N-{2-[(2-amino-1-benzyl-2-oxoethyl)amino]-2-oxoethyl}carbamate 
• 17337-67-6 L--Phe-amid 
• 5241-68-9 Z-Asp(OBzl)-Phe-NH₂ 
• 17337-73-4 N-Benzyloxycarbonyl-O-tert.-butyl-Ser-Phe-amid 
• 81092-90-2 benzyloxycarbonyl-α-tert-butyl-L-aspartyl-β-L-phenylalanine amide 
• 17337-66-5 N-Benzyloxycarbonyl-γ-O-tert.-butyl-Glu-Phe-amid 
• 17471-89-5 carbobenzoxy-β-alanyl-L-phenylalanine amide 
• 17337-71-2 N-Benzyloxycarbonyl-L-norvalyl-Phe-amid 
• 129095-57-4 Z-Asn-Phe-NH₂ 
• 17327-61-6 N-Benzyloxycarbonyl-L-α-aminobuttersaeure-Phe-amid 
• 33900-18-4 Cam-3508 
• 38678-60-3 leucylphenylalanylamide 
• 27220-69-5 Boc-Ala-Phe-NH₂ 
• 33900-15-1 (2S)-N-[(1S)-2-amino-1-benzyl-2-oxoethyl]-2-[(tert-butoxycarbonyl)amino]-4-methylpentanamide 

Relevant articles and documents

Mechanism of fluorescence quenching of tyrosine derivatives by amide group

The difference between fluorescence lifetimes of the following amino acids: phenylalanine (Phe), tyrosine (Tyr), (O-methyl)tyrosine (Tyr(Me)), (3-hydroxy)tyrosine (Dopa), (3,4-dimethoxy)phenylalanine (Dopa(Me)2) and their amides was used to tes

Mechanochemical Synthesis of Primary Amides

Ball milling of aromatic, heteroaromatic, vinylic, and aliphatic esters with ethanol and calcium nitride afforded the corresponding primary amides in a transformation that was compatible with a variety of functional groups and maintained the integrity of a stereocenter α to carbonyl. This methodology was applied to α-amino esters and N-BOC dipeptide esters and also to the synthesis of rufinamide, an antiepileptic drug.

ANALOGS THAT TARGET MITOCHONDRIAL DISEASES

Disclosed are analogs of elamipretide (MTP-131). The compounds are useful for the treatment and prevention of ischemia-reperfusion injury (e.g., cardiac ischemia-reperfusion injury) or myocardial infarction.