6283-81-4

Basic information

• Product Name: 3-OXO-3-PYRIDIN-3-YL-PROPIONIC ACID ETHYL ESTER
• Synonyms: TIMTEC-BB SBB010886;ETHYL 3-OXO-3-(3-PYRIDYL)PROPIONATE;ETHYL-3-PYRIDOYL ACETATE;3-OXO-3-PYRIDIN-3-YL-PROPIONIC ACID ETHYL ESTER;ethyl 3-oxo-3-pyridin-3-ylpropanoate(SALTDATA: FREE);Ethyl 3-oxo-3-(3-pyridinyl)propionate;3-keto-3-(3-pyridyl)propionic acid ethyl ester;3-oxo-3-(3-pyridyl)propanoic acid ethyl ester
• CAS NO: 6283-81-4
• Molecular Formula: C₁₀H₁₁NO₃
• Molecular Weight: 193.2
• Mol File: 6283-81-4.mol
• Article Data: 26

Chemical Properties

• Boiling Point: 298 °C at 760 mmHg
• Flash Point: 134.1 °C
• Appearance: /
• Density: 1.155 g/cm³
• Vapor Pressure: 0.0013mmHg at 25°C
• Refractive Index: 1.51
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• CAS DataBase Reference: 3-OXO-3-PYRIDIN-3-YL-PROPIONIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-OXO-3-PYRIDIN-3-YL-PROPIONIC ACID ETHYL ESTER(6283-81-4)
• EPA Substance Registry System: 3-OXO-3-PYRIDIN-3-YL-PROPIONIC ACID ETHYL ESTER(6283-81-4)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 6283-81-4(Hazardous Substances Data)

Usage

General Description

3-OXO-3-PYRIDIN-3-YL-PROPIONIC ACID ETHYL ESTER, also known as ethyl 3-oxo-3-(pyridin-3-yl)propanoate, is an organic compound with the chemical formula C11H11NO3. It is a derivative of pyridine and is commonly used as an intermediate in the pharmaceutical industry for the synthesis of various drugs. 3-OXO-3-PYRIDIN-3-YL-PROPIONIC ACID ETHYL ESTER has an ester functional group, which makes it useful for the formation of ester bonds in organic synthesis. It has potential applications in medicinal chemistry, particularly in the development of new drugs with pyridine moieties. Additionally, it can also be used as a building block in the production of other organic compounds.

InChI:InChI=1/C10H11NO3/c1-2-14-10(13)6-9(12)8-4-3-5-11-7-8/h3-5,7H,2,6H2,1H3

Upstream product

• 614-18-6 3-pyridinecarboxylic acid ethyl ester 
• 141-78-6 ethyl acetate 
• 4013-72-3 nicotinoyl azide 
• 1007476-32-5 sodium ethyl acetylacetate enolate 
• 350-03-8 methyl-3-pyridylketone 
• 105-58-8 Diethyl carbonate 
• 59-67-6 nicotinic acid 
• 6148-64-7 ethyl potassium malonate 
• 37892-24-3 potassium diethyl malonate 
• 59846-45-6 nicotinoyl imidazolide 
• 626-55-1 3-Bromopyridine 
• 15226-74-1 dicobalt octacarbonyl 
• 141-97-9 ethyl acetoacetate 
• 82102-37-2 9-methyl-9H-fluorene-9-carbonyl chloride 

Downstream Products

• 94678-45-2 1,3,5-tris(3-pyridyl)pentane-1,5-dione 
• 54109-95-4 diethyl 3-pyridylcarbonylsuccinate 
• 350-03-8 methyl-3-pyridylketone 
• 6221-12-1 3-Bromoacetylpyridine 
• 86966-71-4 2,3-dihydro-6-hydroxy-3-oxo-2-phenyl-4-(β-pyridyl)-pyrazolo<3,4-b>pyridine 
• 476468-54-9 3-(Dibromoacetyl)pyridine hydrobromide 
• 1215002-56-4 1-(4-fluorophenyl)-3-(pyridin-3-yl)-1H-pyrazol-5-ol 
• 1378868-68-8 ethyl 6-(N-(4-bromo-3-fluorobenzyl)methylsulfonamido)-5-cyclopropyl-2-(pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxylate 
• 1378868-70-2 6-(N-(4-bromo-3-fluorobenzyl)methylsulfonamido)-5-cyclopropyl-2-(pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxylic acid 
• 1378868-72-4 6-(N-(4-bromo-3-fluorobenzyl)methylsulfonamido)-5-cyclopropyl-N-methyl-2-(pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide 
• 1378868-74-6 5-cyclopropyl-6-(N-(3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)methylsulfonamido)-N-methyl-2-(pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide 
• 1378868-34-8 (4-((N-(5-cyclopropyl-3-(methylcarbamoyl)-2-(pyridin-3-yl)pyrazolo[1,5-a]pyridin-6-yl)methylsulfonamido)methyl)-2-fluorophenyl)boronic acid 
• 1629162-14-6 (R)-benzyl 3-tert-butyl-4-oxo-1-(pyridin-3-yl)-2,3-diazaspiro[4.4]nona-1,7-diene-7-carboxylate 
• 136757-10-3 ethyl 3-amino-3-(pyridin-3-yl)acrylate 

Relevant articles and documents

Amide/Ester Cross-Coupling via C-N/C-H Bond Cleavage: Synthesis of β-Ketoesters

Activated primary, secondary, and tertiary amides were coupled with enolizable esters in the presence of LiHMDS to obtain good yields of β-ketoesters at room temperature. Notably, this protocol provides an efficient, mild, and high chemoselectivity method

Compounds with coumarin-biphenyl skeleton, and preparation method and application of compounds

The invention belongs to the field of pharmaceutical chemistry, and discloses compounds with a coumarin-biphenyl skeleton, and a preparation method and application of the compounds. The compounds havefollowing structural general formulae. The preparation method of the two compounds is simple and reliable, and the total yield is 40% or above. Preliminary pharmacological experiments show that the compounds have a certain relaxation effect on an in-vitro arterial blood vessel of a rat, and can be used for development of antihypertensive drugs.

Method for synthesizing 3-acetylpyridine by using high-performance catalyst

In order to solve the technical problems of complicated raw materials and flow, danger and low yield of a traditional 3-acetylpyridine synthesis method in the prior art, the invention provides a method for synthesizing 3-acetylpyridine by using a high-performance catalyst. The method comprises the concrete steps of carrying out transesterification: adopting niacin as a raw material, and carrying out transesterification on the niacin and ethyl acetate under the catalysis of the high-efficiency catalyst for transesterification, wherein the high-efficiency catalyst for transesterification is titanium dioxide and sodium ethoxide; carrying out condensation reaction: after completely carrying out transesterification, adding new ethyl acetate and a high-efficiency catalyst for condensation reaction so as to carry out condensation reaction, and obtaining a midbody I, wherein the high-efficiency catalyst for condensation reaction is sodium ethoxide or a mixture of the sodium ethoxide and titanium dioxide; hydrolyzing and refining: carrying out acid hydrolysis on the obtained midbody I so as to obtain a 3-acetylpyridine crude product, and refining to obtain a 3-acetylpyridine finished product. The synthesis method provided by the invention has the characteristics of short synthesis route, high yield, low cost, high product purity, simplicity in operation, suitability for large-scale industrial production and the like.