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CLAVACIN

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Name

CLAVACIN

EINECS 205-735-2
CAS No. 149-29-1 Density 1.52 g/cm3
PSA 55.76000 LogP -0.29790
Solubility Soluble in water Melting Point 108-111 °C
Formula C7H6 O4 Boiling Point 513.7 °C at 760 mmHg
Molecular Weight 154.13 Flash Point 226.8 °C
Transport Information UN 3462 6.1/PG 2 Appearance white Crystalline
Safety 45-36/37 Risk Codes 25-38-48/20/22-40-22
Molecular Structure Molecular Structure of 149-29-1 (PATULIN) Hazard Symbols ToxicTHarmfulXn
Synonyms

Patulin(6CI); 4-Hydroxy-4H-furo[3,2-c]pyran-2(6H)-one; Acetic acid,(2,4-dihydroxy-2H-pyran-3(6H)-ylidene)-, 3,4-lactone; Clairformin; Clavacin;Clavatin; Claviformin; DL-Patulin; Expansin; Expansin (antibiotic); Expansine;Mycoin; Mycoin C; Mycoin C3; NSC 32951; NSC 8120; Patuline; Penicidin; Terinin

 

CLAVACIN Chemical Properties

Product Name: Clavacin (CAS NO.149-29-1)


Molecular Formula: C7H6O4
Molecular Weight: 154.12g/mol
Mol File: 149-29-1.mol
Einecs: 205-735-2
Appearance: White crystals or fine crystalline powder
Melting Point: 108-111 °C
Boiling point: 513.7 °C at 760 mmHg
Storage Temperature: −20°C
Flash Point: 226.8 °C
Density: 1.52 g/cm3
Water Solubility: Soluble in water
Surface Tension: 58 dyne/cm
Enthalpy of Vaporization: 90.37 kJ/mol
Vapour Pressure: 1.06E-12 mmHg at 25°C
XLogP3-AA: -1
H-Bond Donor: 1
H-Bond Acceptor: 4

CLAVACIN Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
chicken LD50 unreported 170mg/kg (170mg/kg)   Reviews of Environmental Contamination and Toxicology. Vol. 113, Pg. 47, 1990.
dog LD50 intravenous 10mg/kg (10mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: FOOD INTAKE (ANIMAL)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Food and Cosmetics Toxicology. Vol. 17, Pg. 605, 1979.
hamster LD50 intraperitoneal 10mg/kg (10mg/kg)   Food and Cosmetics Toxicology. Vol. 18, Pg. 173, 1980.
hamster LD50 oral 31500ug/kg (31.5mg/kg)   Food and Cosmetics Toxicology. Vol. 18, Pg. 173, 1980.
hamster LD50 subcutaneous 23mg/kg (23mg/kg)   Food and Cosmetics Toxicology. Vol. 18, Pg. 173, 1980.
mouse LD50 intracrebral 570ug/kg (0.57mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Toxicology. Vol. 13, Pg. 91, 1979.
mouse LD50 intraperitoneal 5mg/kg (5mg/kg)   Acta Pharmacologica et Toxicologica. Vol. 2, Pg. 109, 1946.
mouse LD50 intravenous 5mg/kg (5mg/kg)   "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 5, Pg. 439, 1981.
mouse LD50 oral 17mg/kg (17mg/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

LIVER: FATTY LIVER DEGERATION

KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Toxicology and Applied Pharmacology. Vol. 45, Pg. 275, 1978.
mouse LD50 subcutaneous 10mg/kg (10mg/kg) BEHAVIORAL: EXCITEMENT

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Food and Cosmetics Toxicology. Vol. 18, Pg. 181, 1980.
mouse LDLo unreported 8mg/kg (8mg/kg)   British Journal of Cancer. Vol. 15, Pg. 85, 1961.
rabbit LDLo intravenous 12mg/kg (12mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: PLEURAL EFFUSION
Lancet. Vol. 245, Pg. 631, 1943.
rat LD50 intraperitoneal 4590ug/kg (4.59mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

GASTROINTESTINAL: OTHER CHANGES
Annales Recherches Veterinaires. Vol. 8, Pg. 41, 1977.
rat LD50 intravenous 8570ug/kg (8.57mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

GASTROINTESTINAL: OTHER CHANGES
Annales Recherches Veterinaires. Vol. 8, Pg. 41, 1977.
rat LD50 oral 27790ug/kg (27.79mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

GASTROINTESTINAL: OTHER CHANGES
Annales Recherches Veterinaires. Vol. 8, Pg. 41, 1977.
rat LD50 subcutaneous 11mg/kg (11mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Food and Chemical Toxicology. Vol. 20, Pg. 289, 1982.

CLAVACIN Consensus Reports

IARC Cancer Review: Group 3 IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 , 1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Limited Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 10 , 1976,p. 205.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Inadequate Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 40 , 1986,p. 83.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program.

CLAVACIN Safety Profile

Poison by ingestion, subcutaneous, intracerebral, intraperitoneal, intravenous, and possibly other routes. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. Questionable carcinogen with experimental neoplastigenic and teratogenic data. An antimicrobial agent. When heated to decomposition it emits acrid smoke and irritating fumes.
Safety Information of Clavacin (CAS NO.149-29-1):
Hazard Codes: T,Xn,C,F
Risk Statements: 25-38-48/20/22-40-22-34-11 
11:  Highly Flammable
20:  Harmful by inhalation
22:  Harmful if swallowed
25:  Toxic if swallowed
34:  Causes burns
38:  Irritating to the skin
40:  Limited evidence of a carcinogenic effect
48:  Danger of serious damage to health by prolonged exposure
Safety Statements: 45-36/37-36/37/39-26-16
16:  Keep away from sources of ignition - No smoking
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36:  Wear suitable protective clothing  
37:  Wear suitable gloves 
39:  Wear eye/face protection 
45:  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)

CLAVACIN Specification

 Clavacin ,its CAS NO. is 149-29-1,the synonyms is (2,4-Dihydroxy-2h-pyran-3(6h)-ylidene)aceticacid-3,4-lactone;2,4-dihydroxy-2h-pyran-delta-3(6h),alpha-aceticacid-3,4-lactone ; 2-C(pyran-2(6h)-one,4-hydroxy-4h-furo) ; 2H-pyran-delta(sup3(6h),alpha)-aceticacid,2,4-dihydroxy-,3,4-lactone ; Aceticacid,(2,4-dihydroxy-2h-pyran-3(6h)-ylidene)-,3,4-lactone ; Clairformin ; Patulin .

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