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Candesartan cilexetil

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Name

Candesartan cilexetil

EINECS
CAS No. 145040-37-5 Density 1.37 g/cm3
Solubility Melting Point
Formula C33H34N6O6 Boiling Point 843.3 ºC at 760 mmHg
Molecular Weight 610.67 Flash Point 463.8 ºC
Transport Information Appearance White crystalline powder
Safety 26-36 Risk Codes 20/21/22-36/37/38
Molecular Structure Molecular Structure of 145040-37-5 (Candesartan cilexetil) Hazard Symbols HarmfulXn
Synonyms

1H-Benzimidazolium, 7-carboxy-1-(2-((cyclohexylcarbonyl)oxy)ethyl)-2-ethoxy-1-(2-(1H-tetrazol-5-yl)(1,1-biphenyl)-4-yl)-, hydroxide, inner salt, (+-)-;TCV-116;Atacand;Atacand (TN);1-cyclohexyloxycarbonyloxyethyl 2-ethoxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]benzoimidazole-4-carboxylate;TCV 116;Candesartancilexetil;

 

Candesartan cilexetil Specification

1. Introduction of Candesartan cilexetil
Candesartan cilexetil is one kind of white or off white powder. The IUPAC Name of it is 1-cyclohexyloxycarbonyloxyethyl 2-ethoxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate. It belongs to Antihypertensive;API;APIs;Hypertension;Bases & Related Reagents;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;Candesartan;Heterocycles. The Classification Code of it is Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Antagonist [angiotensin II receptor]; Antihypertensive; Antihypertensive agents; Cardiovascular Agents; Drug / Therapeutic Agent.

2. Properties of Candesartan cilexetil
Physical properties about Candesartan cilexetil are:
(1)Index of Refraction: 1.666; (2)Molar Refractivity: 165.46 cm3; (3)Molar Volume: 444.6 cm3; (4)Surface Tension: 54 dyne/cm; (5)Density: 1.37 g/cm3; (6)Flash Point: 463.8 °C; (7)Enthalpy of Vaporization: 122.54 kJ/mol; (8)Boiling Point: 843.3 °C at 760 mmHg; (9)Vapour Pressure of Candesartan cilexetil: 1.11E-28 mmHg at 25 °C.

3. Structure Descriptors of Candesartan cilexetil
(1)SMILES: c1cc(c2c(c1)nc(OCC)n2Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)C(O[C@@H](OC(OC1CCCCC1)=O)C)=O
(2)InChI: InChI=1/C33H34N6O6/c1-3-42-32-34-28-15-9-14-27(31(40)43-21(2)44-33(41)45-24-10-5-4-6-11-24)29(28)39(32)20-22-16-18-23(19-17-22)25-12-7-8-13-26(25)30-35-37-38-36-30/h7-9,12-19,21,24H,3-6,10-11,20H2,1-2H3,(H,35,36,37,38)
(3)InChIKey: InChIKey=GHOSNRCGJFBJIB-UHFFFAOYSA-N

4. Toxicity of Candesartan cilexetil

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 2gm/kg (2000mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 42, Pg. 406, 2000.
mouse LD50 intraperitoneal 807mg/kg (807mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 24(Suppl,
mouse LD50 oral > 2gm/kg (2000mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 24(Suppl,
rat LD50 intraperitoneal 940mg/kg (940mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 24(Suppl,
rat LD50 oral > 2gm/kg (2000mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 24(Suppl,

5. Safety of Candesartan cilexetil
Hazard Codes: HarmfulXn
Risk Statements: 20/21/22-36/37/38 
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed. 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements of Candesartan cilexetil (CAS NO.145040-37-5): 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36:Wear suitable protective clothing.

6. Uses of Candesartan cilexetil
Candesartan cilexetil (CAS NO.145040-37-5) is used in treatment of congestive heart failure. As an antihypertensive, it will be used in treatment of congestive heart failure.

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