Basic information
- Name:
Capreomycin
- CAS No.:
11003-38-6
- Molecular Structure:
- Synonyms:
- Capastat;Capostatin; Capreomicin; Capromycin
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Chemistry
Chemistry informtion about Capreomycin (CAS NO.11003-38-6) is:
IUPAC Name: 3,6-diamino-N-[[(4Z)-11-amino-7-(2-amino-1,4,5,6-tetrahydropyrimidin-6-yl)-4-[(carbamoylamino)methylidene]-14-(hydroxymethyl)-2,5,8,12,15-pentaoxo-3,6,9,13,16-pentazacyclohexadec-1-yl]methyl]hexanamide; sulfuric acid
Synonyms: 3,6-Diamino-N-[[(8z)-15-Amino-11-(2-Amino-3,4,5,6-Tetrahydropyrimidin-4-Yl)-2-(Hydroxymethyl)-3,6,9,12,16-Pentaoxo-8-(Ureidomethylene)-1,4,7,10,13-Pentazacyclohexadec-5-Yl]Methyl]Hexanamide ; Sulfuric Acid
MF: C25H46N14O12S
MW: 766.7843
Flash Point: 786.4 °C
Boiling Point: 1376.7 °C at 760 mmHg
Enthalpy of Vaporization: 234.62 kJ/mol
Following is the molecular structure of Capreomycin (CAS NO.11003-38-6) is:
Production
Raw materials: Cation exchange resin,strong acidic styrene --> Cation exchange resin,weak acidic acrylic acid
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| man | TDLo | oral | 1371mg/kg/96D (1371mg/kg) | vascular: bp elevation not characterized in autonomic section | American Journal of Kidney Diseases. Vol. 7, Pg. 245, 1986. |
| mouse | LD50 | intravenous | 238mg/kg (238mg/kg) | Yakkyoku. Pharmacy. Vol. 25, Pg. 353, 1974. | |
| mouse | LD50 | oral | > 5gm/kg (5000mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 9, Pg. 861, 1967. | |
| mouse | LD50 | subcutaneous | 514mg/kg (514mg/kg) | Yakkyoku. Pharmacy. Vol. 25, Pg. 353, 1974. |
Safety Profile
A poison by intravenous route. Moderately toxic by subcutaneous route. Low toxicity by ingestion. Human systemic effects. When heated to decomposition it emits acrid smoke and irritating vapors.
Specification
Capreomycin (CAS NO.11003-38-6) is a peptide antibiotic, commonly grouped with the aminoglycosides, which is given in combination with other antibiotics for tuberculosis. Adverse effects include nephrotoxicity and 8th cranial nerve toxicity.The drug should not be given with streptomycin or other drugs that may damage the 8th nerve.
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