Basic information
- Name:
Cefotaxime sodium
- CAS No.:
64485-93-4
- Molecular Structure:
- Formula:
- C16H16N5NaO7S2
- Synonyms:
- cefotaxim sodium salt;Cefotaxime Sodium (Sterile);Cefotaxime free acid;RU 24662;Liquiritin;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;sodium [6R-[6α,7β(Z)]]-3-(acetoxymethyl)-7-[(2-aminothiazol-4-yl)(methoxyimino)acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;Sodium (6R,7R)-7-(2-(2-amino-4-thiazolyl)glyoxylamido)-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate 7(sup 2)-(Z)-(O-methyloxime), acetate (ester);Claforan (TN);Sodium 7-(2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido)cephalosporanate;Cefotaxime sodium (JP14/USP);HR 756;Claforan sodium;Cefotaxime sodium salt;sodium (6R,7R)-3-(acetyloxymethyl)-7-[[2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;63527-52-6;Cefotaxime Sodium. Sterile;Cefotaxima [INN-Spanish];Cefotaxime sodium [USAN:JAN];sodium (6R,7R)-3-(acetyloxymethyl)-7-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;Sodium (6R-(6alpha,7beta(Z)))-3-(acetoxymethyl)-7-((2-aminothiazol-4-yl)(methoxyimino)acetamido)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate;Prestwick_823;RU 24756;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-, (6R,7R)-;(+)-Cefotaxime sodium salt;Sodium cefotaxime;Tolycar;(6S,7S)-3-(acetyloxymethyl)-7-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-((acetyloxy)methyl)-7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-8-oxo-, monosodium salt, (6R-(6alpha,7beta(Z)))-;Cefotaxime Sodium sterile;
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Chemistry
Empirical Formula: C16H17N5O7S2
Molecular Weight: 455.4655
EINECS: 264-915-9
Index of Refraction: 1.778
Density: 1.8 g/cm3
Melting point: 162-163 °C(lit.)
Storage tempreture: 2-8 °C
Appearance: White to pale yellow crystalline powder
Structure of Cefotaxime sodium (CAS NO.64485-93-4):
IUPAC Name: Sodium (6R,7R)-3-(acetyloxymethyl)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Canonical SMILES: CC(=O)OCC1=C(N2C(C(C2=O)NC(=O)C(=NOC)C3=CSC(=N3)N)SC1)C(=O)[O-].[Na+]
Isomeric SMILES: CC(=O)OCC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)/C(=N\OC)/C3=CSC(=N3)N)SC1)C(=O)[O-].[Na+]
InChI: InChI=1S/C16H17N5O7S2.Na/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8;/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26);/q;+1/p-1/b20-9-;/t10-,14-;/m1./s1
InChIKey: AZZMGZXNTDTSME-JUZDKLSSSA-M
Product Category of Cefotaxime sodium (CAS NO.64485-93-4): API;Antibiotics for Research and Experimental Use;Biochemistry;Antibiotic Explorer;Heterocycles;Intermediates & Fine Chemicals;Sulfur & Selenium Compounds
Uses
Cefotaxime sodium (CAS NO.64485-93-4) can be used as antibiotic medicine for the treatment of respiratory, urinary, intestinal and biliary tract, skin and soft tissue, burns, and bone and joint infections and other diseases.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| child | TDLo | intravenous | 1800mg/kg/18D (1800mg/kg) | BLOOD: AGRANULOCYTOSIS | Drug Intelligence and Clinical Pharmacy. Vol. 17, Pg. 739, 1983. |
| dog | LD50 | intramuscular | > 716mg/kg (716mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 349, 1982. | |
| dog | LD50 | intravenous | > 1500mg/kg (1500mg/kg) | Journal of Antimicrobial Chemotherapy. Vol. 6(Suppl, | |
| mouse | LD50 | intraperitoneal | 10gm/kg (10000mg/kg) | Drugs in Japan Vol. 6, Pg. APP-8, 1982. | |
| mouse | LD50 | intravenous | 6845mg/kg (6845mg/kg) | Antibiotiki i Khimioterapiya. Antibiotics and Chemotherapy. Vol. 35(5), Pg. 25, 1990. | |
| mouse | LD50 | oral | > 20gm/kg (20000mg/kg) | BEHAVIORAL: FOOD INTAKE (ANIMAL) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: ATAXIA | Chemotherapy Vol. 28(Suppl, |
| mouse | LD50 | subcutaneous | 12950mg/kg (12950mg/kg) | Drugs in Japan Vol. 6, Pg. APP-8, 1982. | |
| rabbit | LD50 | intravenous | 1880mg/kg (1880mg/kg) | BEHAVIORAL: FOOD INTAKE (ANIMAL) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: ATAXIA | Chemotherapy Vol. 28(Suppl, |
| rat | LD50 | intramuscular | > 2gm/kg (2000mg/kg) | Chemotherapy Vol. 28(Suppl, | |
| rat | LD50 | intraperitoneal | 10gm/kg (10000mg/kg) | BEHAVIORAL: FOOD INTAKE (ANIMAL) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: ATAXIA | Chemotherapy Vol. 28(Suppl, |
| rat | LD50 | intravenous | 7gm/kg (7000mg/kg) | Drugs in Japan Vol. 6, Pg. APP-8, 1982. | |
| rat | LD50 | oral | > 20gm/kg (20000mg/kg) | BEHAVIORAL: FOOD INTAKE (ANIMAL) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Chemotherapy Vol. 28(Suppl, |
| rat | LD50 | subcutaneous | 18400mg/kg (18400mg/kg) | BEHAVIORAL: FOOD INTAKE (ANIMAL) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Chemotherapy Vol. 28(Suppl, |
Safety Profile
Moderately toxic by intravenous and intramuscular routes. Mildly toxic by ingestion and intraperitoneal routes. Human systemic effects by intravenous route: agranulocytosis. An experimental teratogen. When heated to decomposition it emits toxic fumes of SOx, NOx and Na2O.
Hazard Codes: 
Xn,
Xi(Harmful)
Risk Statements:
R42/43 (May cause sensitization by inhalation and skin contact )
Safety Statements:
S22:Do not breathe dust
S36/37 :Wear suitable protective clothing and gloves
WGK Germany: 2
Specification
Cefotaxime sodium , its cas register number is 64485-93-4. It also can be called Claforan ; CTX ; and [6R-[6alpha,7beta(z)]]-3-[(Acetyloxy)methyl]-[[(2-amine-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid monosodium salt .
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