Ceftibuten (97519-39-6),Ceftibuten (97519-39-6) Manufacturers & Suppliers,Synthesis,MSDS

Basic information

Name:
Ceftibuten
CAS No.:
97519-39-6
Molecular Structure:
Formula:
C₁₅H₁₄N₄O₆S₂
Molecular Weight:
410.42
Synonyms:
Ceftibuten [USAN:BAN:INN];Ceftibutin;Ceftibutene;Cephalosporin 7432-S;Ceftibutene [INN-French];Cedax (TN);Ceftibuten (USAN);Ceftibuteno [INN-Spanish];Cedax;Ceftibutenum [INN-Latin];5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((2-(2-amino-4-thiazolyl)-4-carboxy-1-oxo-2-butenyl)amino)-8-oxo-, (6R-(6alpha,7beta(Z)))-;Sch 39720;(+)-(6R,7R)-7-((Z)-2-(2-Amino-4-thiazolyl)-4-carboxycrotonamido)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid;Cephem;
Density:
1.75 g/cm³
Boiling Point:
966.4 °C at 760 mmHg
Flash Point:
538.3 °C

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Chemistry

Structure of Ceftibuten (CAS NO.97519-39-6):

IUPAC Name: (6R,7R)-7-[[(E)-2-(2-amino-1,3-thiazol-4-yl)-5-hydroxy-5-oxopent-2-enoyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Molecular Formula:C₁₅H₁₄N₄O₆S₂
Molar mass:410.4249g/mol
H bond acceptors: 10
H bond donors: 5
Freely Rotating Bonds: 6
Polar Surface Area: 162.89 Å²
Index of Refraction: 1.762
Molar Refractivity: 96.19 cm³
Molar Volume: 233.3 cm³
Density: 1.75 g/cm³
Flash Point: 538.3 °C
Boiling Point: 966.4 °C at 760 mmHg
Index of Refraction: 1.762
Vapour Pressure: 0 mmHg at 25°C
Surface Tension: 112.1 dyne/cm
Product Categories: API
Synonyms of Ceftibuten (CAS NO.97519-39-6): trans-Ceftibuten ; Ceftibutene ; cis-Ceftibutin ; Ceftibutenum ; Ceftibuteno ; Cedax ; Cephem ; 7-[2-(2-amino-1,3-thiazol-4-yl)-4-carboxyisocrotonamide]-3-cephem-4-carboxylic acid ; (6r-(6-alpha,7-beta(z)))-yl)-4-carboxy-1-oxo-2-butenyl)amino)-8-oxo ; cephem;cis-ceftibutin

Production

Compounds (I) and formic acid diphenyl methyl ester dissolved in tetrahydrofuran, in the presence of sodium hydride, at 0 ~ 20°C, react 2h for getting the availability of high-yield compound (1I). (Ⅱ) and organic phosphorus reagents get Wittig reaction to be compound (Ⅲ). Then with trifluoroacetic acid in dichloromethane at 0 ~ 5 °C reaction 1.5h, hydrolysis, to get compound (Ⅳ). Then with cephalosporin (V), according to ordinary method, obtained compound (Ⅵ) . Finally, in the presence of aluminum chloride with anisole, heating to get.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	oral	> 5gm/kg (5000mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: NAUSEA OR VOMITING	Chemotherapy Vol. 37(Suppl,
rat	LD50	oral	> 10gm/kg (10000mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: OTHER CHANGES	Chemotherapy Vol. 37(Suppl,

Specification

Ceftibuten (CAS NO.97519-39-6) is used urinary tract infections, respiratory infections and gynecological infections caused by the susceptible ones.