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Basic information

  • Name:

  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-,sodium salt (1:2), (6R,7R)-

  • Superlist Name:
  • Ceftriaxone sodium
  • CAS No.:

  • 74578-69-1

  • Formula:
  • C18H18N8Na2O7S3
  • Synonyms:
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-,disodium salt, [6R-[6a,7b(Z)]]-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-,disodium salt, (6R,7R)- (9CI);Acantex;Cefatriaxone;Ceftriaxone disodium;Ceftriaxone disodium salt;Cephtriaxone;Ceroneed;Disodiumceftriaxone;Lendacin;Longaceph;Monocef;Oframax;Ro 13-9904;Rocephin;Sefirom;Tartriakson;X 13-9904;Ceftriaxone Sodium Hydrate;

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Specification

The Ceftriaxone Sodium is an organic compound with the formula C18H18N8Na2O7S3. The systematic name of this chemical is disodium (6R,7R)-7-[[(2Z)-2-(2-aminothiazol-4-yl)-2-methoxyimino-acetyl]amino]-3-[(6-hydroxy-2-methyl-5-oxo-1,2,4-triazin-3-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid. With the CAS registry number 74578-69-1, it is also named as Ceftriaxone disodium.

You can still convert the following datas into molecular structure:
(1)SMILES: Cn1c(nc(=O)c(n1)O)SCC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)/C(=N\OC)/c4csc(n4)N)SC2)C(=O)O.[Na+].[Na+]
(2)InChI: InChI=1/C18H18N8O7S3.2Na/c1-25-18(22-12(28)13(29)23-25)36-4-6-3-34-15-9(14(30)26(15)10(6)16(31)32)21-11(27)8(24-33-2)7-5-35-17(19)20-7;;/h5,9,15H,3-4H2,1-2H3,(H2,19,20)(H,21,27)(H,23,29)(H,31,32);;/q;2*+1/b24-8-;;/t9-,15-;;/m1../s1
(3)InChIKey: FDRNWTJTHBSPMW-BBJOQENWBW
(4)Std. InChI: InChI=1S/C18H18N8O7S3.2Na/c1-25-18(22-12(28)13(29)23-25)36-4-6-3-34-15-9(14(30)26(15)10(6)16(31)32)21-11(27)8(24-33-2)7-5-35-17(19)20-7;;/h5,9,15H,3-4H2,1-2H3,(H2,19,20)(H,21,27)(H,23,29)(H,31,32);;/q;2*+1/b24-8-;;/t9-,15-;;/m1../s1
(5)Std. InChIKey: FDRNWTJTHBSPMW-BBJOQENWSA-N

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous > 3gm/kg (3000mg/kg)   Drugs in Japan Vol. -, Pg. 676, 1995.
infant TDLo intramuscular 16mg/kg/3D-I (16mg/kg) BRAIN AND COVERINGS: MENINGEAL CHANGES

BLOOD: CHANGES IN LEUCOCYTE (WBC) COUNT		 Clinical Pediatrics Vol. 32, Pg. 360, 1993.
man TDLo multiple routes 800mg/kg/49D- (800mg/kg) BLOOD: AGRANULOCYTOSIS

BLOOD: CHANGES IN LEUCOCYTE (WBC) COUNT		 Israel Journal of Medical Sciences. Vol. 29, Pg. 52, 1993.
mouse LD50 intravenous 2200mg/kg (2200mg/kg)   Journal of Antibiotics. Vol. 33, Pg. 783, 1980.
mouse LD50 oral > 10gm/kg (10000mg/kg)   "Ceftriaxon Vol. -, Pg. 91, 1982.
mouse LD50 subcutaneous > 5gm/kg (5000mg/kg)   "Ceftriaxon Vol. -, Pg. 91, 1982.
rat LD50 intravenous 1900mg/kg (1900mg/kg)   "Ceftriaxon Vol. -, Pg. 91, 1982.
rat LD50 oral > 10gm/kg (10000mg/kg)   "Ceftriaxon Vol. -, Pg. 91, 1982.
rat LD50 subcutaneous > 5gm/kg (5000mg/kg)   "Ceftriaxon Vol. -, Pg. 91, 1982.
women TDLo multiple routes 640mg/kg/32D- (640mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BLOOD: AGRANULOCYTOSIS		 Israel Journal of Medical Sciences. Vol. 29, Pg. 52, 1993.

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