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Cephalexin

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Name

Cephalexin

EINECS 239-773-6
CAS No. 15686-71-2 Density 1.5 g/cm3
PSA 138.03000 LogP 1.47400
Solubility NH4OH 1 M: 50 mg/mL, clear, yellow Melting Point 196-198 °C
Formula C16H17N3O4S Boiling Point 727.4°C at760mmHg
Molecular Weight 347.395 Flash Point 393.7°C
Transport Information N/A Appearance white crystalline powder
Safety 22-36/37-45 Risk Codes 42/43
Molecular Structure Molecular Structure of 15686-71-2 (Cephalexin) Hazard Symbols HarmfulXn
Synonyms

Sencephalin;Septilisin;Sialexin;Sinthecillin;Sporidex;Syncle;Tepaxin;Uphalexin;Vetolexin;Winlex;Alcephin;Biocef;Cefablan;Cefadina;Cefalexin;Cefaloto;Ceforal;Celexin;Cepexin;

Article Data 27

Cephalexin Chemical Properties

Molecular Structure of Cephalexin (CAS NO.15686-71-2): 
   
CAS Number: 15686-71-2
Molecular Formula: C16H17N3O4S
Molecular Weight: 347.39
EINECS: 239-773-6
Density: 1.5g/cm3
Melting Point: 196-198°C
Boiling Point: 727.4°C at760mmHg
Flash Point: 393.7°C
Appearance: white crystalline powder
Liansport Information: Hazard
Storage temp: 2-8°C
Solubility: NH4OH 1 M: 50 mg/mL
Merck: 13,1986
CAS DataBase Reference: 15686-71-2(CAS DataBase Reference)
InChI
InChI=1/C16H17N3O4S/c1-8-7-24-15-11(14(21)19(15)12(8)16(22)23)18-13(20)10(17)9-5-3-2-4-6-9/h2-6,10-11,15H,7,17H2,1H3,(H,18,20)(H,22,23)/t10-,11-,15-/m1/s1
Smiles
S1[C@@H]2[C@H](NC([C@@H](c3ccccc3)N)=O)C(=O)N2C(C(=O)O)=C(C1)C
Product Categories: Heterocyclic Compounds;Heterocycles; Intermediates & Fine Chemicals; Pharmaceuticals;A - KAntibiotics; Antibacterial; Antibiotics A to; Antibiotics A-FAntibiotics; Chemical Structure Class; Interferes with Cell Wall SynthesisAntibiotics; Mechanism of Action; Penicillins and Cephalosporins (beta-Lactams); Spectrum of Activity

Cephalexin Production

  Cephalexin (CAS NO.15686-71-2) can produced in thie way:to penicillin potassium as raw material, by oxidation, expansion ring, cleavage was 7 - amino acid to the acyl oxy cephalosporin, and then condensation with the side chain derived.

Cephalexin Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intraperitoneal 1gm/kg (1000mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Kiso to Rinsho. Clinical Report. Vol. 3, Pg. 513, 1969.
cat LDLo oral 250mg/kg (250mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: FOOD INTAKE (ANIMAL)

GASTROINTESTINAL: NAUSEA OR VOMITING
Kiso to Rinsho. Clinical Report. Vol. 3, Pg. 513, 1969.
dog LD oral > 1gm/kg (1000mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 3, Pg. 513, 1969.
dog LD50 intraperitoneal > 1gm/kg (1000mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

BEHAVIORAL: FOOD INTAKE (ANIMAL)
Antimicrobial Agents and Chemotherapy Vol. -, Pg. 489, 1968.
guinea pig LDLo intraperitoneal 1gm/kg (1000mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Kiso to Rinsho. Clinical Report. Vol. 3, Pg. 513, 1969.
guinea pig LDLo oral 5gm/kg (5000mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Kiso to Rinsho. Clinical Report. Vol. 3, Pg. 513, 1969.
human TDLo oral 14mg/kg/D (14mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: NAUSEA OR VOMITING
Antimicrobial Agents and Chemotherapy Vol. -, Pg. 361, 1968.
monkey LDLo oral > 1gm/kg (1000mg/kg)   Antimicrobial Agents and Chemotherapy Vol. -, Pg. 489, 1968.
mouse LD50 intraperitoneal 400mg/kg (400mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED
Antimicrobial Agents and Chemotherapy Vol. -, Pg. 489, 1968.
mouse LD50 oral 1495mg/kg (1495mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Chemotherapy Vol. 27(Suppl,
mouse LD50 subcutaneous 1150mg/kg (1150mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

KIDNEY, URETER, AND BLADDER: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 227, 1969.
rabbit LDLo intraperitoneal > 4gm/kg (4000mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Antimicrobial Agents and Chemotherapy Vol. -, Pg. 489, 1968.
rabbit LDLo oral 2500mg/kg (2500mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Kiso to Rinsho. Clinical Report. Vol. 3, Pg. 513, 1969.
rat LD50 intraperitoneal 4gm/kg (4000mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: MUSCLE WEAKNESS
Kiso to Rinsho. Clinical Report. Vol. 3, Pg. 390, 1969.
rat LD50 oral > 20gm/kg (20000mg/kg) BEHAVIORAL: ATAXIA

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Chemotherapy Vol. 27(Suppl,
rat LD50 subcutaneous 6100mg/kg (6100mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 3, Pg. 390, 1969.

Cephalexin Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion and other routes. An experimental teratogen. Other experimental reproductive effects. Human systemic effects by ingestion: nausea, vomiting, and diarrhea. When heated to decomposition it emits very toxic fumes of NOx and SOx.
Safety Information of Cephalexin (CAS NO.15686-71-2).
Hazard Codes: HarmfulXn
Safety Statements: 22-36/37-45
S22: Do not breathe dust. 
S36/37:Wear suitable protective clothing and gloves. 
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
Risk Codes: R42/43
R42/43: May cause sensitization by inhalation and skin contact.
WGK Germany: 3
RTECS: XI0350000

Cephalexin Specification

  Cephalexin , with CAS number of 15686-71-2, can be called (6r-(6alpha,7beta(r*)))-ino)-3-methyl-8-oxo ; 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid,7-((aminophenylacetyl)am;5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid,7-(2-amino-2-phenylaceta ; 7-(d-2-amino-2-phenylacetamido)-3-methyl-delta(sup3)-cephem-4-carboxylica ; 7-(d-2-amino-2-phenylacetamido)-3-methyl-delta3-cephem-4-carboxylicacid ; 7-(d-alpha-aminophenylacetamido)desacetoxycephalosporanicacid ; 7-beta-(d-alpha-amino-alpha-phenylacetylamino)-3-methyl-3-cephem-4-carboxyli . It is a white crystalline powder.The usage of Cephalexin (CAS NO.15686-71-2) is semi-synthetic cephalosporin antibiotic.

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