The MF of Cephalosporin C(61-24-5): C₁₆H₂₁N₃O₈S
The MW of Cephalosporin C(61-24-5): 415.41824
The Structure:
EINECS: 200-501-6
Synonyms: 7-(5-amino-5-carboxyvaleramido)cephalosporanic acid;CAPHALOSPORIN C;(7R)-3-[(Acetyloxy)methyl]-7-[[(R)-5-carboxy-5-amino-1-oxopentyl)amino]cepham-3-ene-4-carboxylic acid;7-(D-5-Amino-5-carboxyvaleramido)-3-(hydrox-ymethyl)-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-Carboxylic acid acetate;5-Thia-1-azabicyclo4.2.0oct-2-ene-2-carboxylic acid, 3-(acetyloxy)methyl-7-(5R)-5-amino-5-carboxy-1-oxopentylamino-8-oxo-, (6R,7R)-; (7R)-3-[(Acetyloxy)methyl]-7-[[(R)-5-carboxy-5-amino-1-oxopentyl]amino]cepham-3-ene-4-carboxylic acid;Aminoadipyl cephalosporin

In1948, cephalosporin compounds were first isolated from cultures of Cephalosporium acremonium from a sewer in Sardinia by Italian scientist Giuseppe Brotzu. He noticed that these cultures produced substances that were effective against Salmonella typhi, the cause of typhoid fever, which had beta-lactamase. Researchers at the Sir William Dunn School of Pathology at the University of Oxford isolated cephalosporin C(61-24-5). The cephalosporin nucleus, 7-aminocephalosporanic acid (7-ACA), was derived from cephalosporin C(61-24-5) and proved to be analogous to the penicillin nucleus 6-aminopenicillanic acid, but it was not sufficiently potent for clinical use. Modification of the 7-ACA side-chains resulted in the development of useful antibiotic agents, and the first agent cephalothin (cefalotin) was launched by Eli Lilly in 1964.